Structure-based redesign of proteins for minimal T-cell epitope content
about
Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent modelsMapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidateRemoving T-cell epitopes with computational protein design.Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate.Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loadsDepletion of T cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo.Toward reducing immunogenicity of enzyme replacement therapy: altering the specificity of human β-glucuronidase to compensate for α-iduronidase deficiency.EpiSweep: Computationally Driven Reengineering of Therapeutic Proteins to Reduce Immunogenicity While Maintaining Function.Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity.HIV-1 and its resistance to peptidic carbohydrate-binding agents (CBAs): an overview.Design and engineering of deimmunized biotherapeutics.A high throughput MHC II binding assay for quantitative analysis of peptide epitopes.
P2860
Q24610025-A548C5B2-C951-4015-9060-65F7C72347CAQ28543006-822363CD-5BC6-40E6-9B72-FD912D7F26FBQ30362724-246378FC-6E10-4009-BF04-412997DD567EQ30363065-C6E3A5CC-4C1C-455D-B475-B79EB762FBFFQ30371474-D44CC48D-A993-493E-B416-C6F64D3870EEQ35638576-3F929217-E931-47F1-B8A4-ACE5B28984E5Q35759492-17EB6237-80B6-46C5-B274-C70D7BC965A3Q36212517-3E7DAEBA-9EBF-40FE-8C4F-A152D3A90FC2Q36399908-059FACBD-D07A-4B98-A0A2-C37820297DDDQ38291704-A820972E-1554-4725-A1F5-E0F8AF874459Q38870681-D73FCDEE-82B0-4C12-B656-DE9AB8290C43Q39766269-286E339B-3240-4C74-9473-F26E24308B2F
P2860
Structure-based redesign of proteins for minimal T-cell epitope content
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Structure-based redesign of proteins for minimal T-cell epitope content
@en
type
label
Structure-based redesign of proteins for minimal T-cell epitope content
@en
prefLabel
Structure-based redesign of proteins for minimal T-cell epitope content
@en
P2093
P2860
P356
P1476
Structure-based redesign of proteins for minimal T-cell epitope content
@en
P2093
Chris Bailey-Kellogg
Karl E Griswold
Yoonjoo Choi
P2860
P304
P356
10.1002/JCC.23213
P577
2013-01-08T00:00:00Z