Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation
about
Detection of substrate-dependent conformational changes in the P450 fold by nuclear magnetic resonance.Optical detection of cytochrome P450 by sensitizer-linked substratesProbing the open state of cytochrome P450cam with ruthenium-linker substratesCrystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzeneIn Crystallo Posttranslational Modification Within a MauG/Pre-Methylamine Dehydrogenase ComplexCrystal Structures of CO and NO Adducts of MauG in Complex with Pre-Methylamine Dehydrogenase: Implications for the Mechanism of Dioxygen ActivationSubstrate and Reaction Specificity of Mycobacterium tuberculosis Cytochrome P450 CYP121: INSIGHTS FROM BIOCHEMICAL STUDIES AND CRYSTAL STRUCTURESCarboxyl Group of Glu113 Is Required for Stabilization of the Diferrous and Bis-Fe IV States of MauGImproving the affinity and activity of CYP101D2 for hydrophobic substratesCrystal structure of cytochrome P-450cam complexed with the (1S)-camphor enantiomerInsight into protein structure and protein-ligand recognition by Fourier transform infrared spectroscopy.Three clusters of conformational states in p450cam reveal a multistep pathway for closing of the substrate access channel.The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesInteractions of cytochrome P450s with their ligands.Protein dynamics in cytochrome P450 molecular recognition and substrate specificity using 2D IR vibrational echo spectroscopy.Analysis of cytochrome P450 CYP119 ligand-dependent conformational dynamics by two-dimensional NMR and X-ray crystallography.Cytochrome P450: what have we learned and what are the future issues?Competitive inhibition of coumarin 7-hydroxylation by pilocarpine and its interaction with mouse CYP 2A5 and human CYP 2A6Characterization of biphenyl dioxygenase of Pandoraea pnomenusa B-356 as a potent polychlorinated biphenyl-degrading enzyme.Identification of a functional water channel in cytochrome P450 enzymes.Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita.Thermodynamics of water mediating protein-ligand interactions in cytochrome P450cam: a molecular dynamics study.Binding of small-molecule ligands to proteins: "what you see" is not always "what you get".New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome.Conformational plasticity and structure/function relationships in cytochromes P450.Conformational Heterogeneity and the Affinity of Substrate Molecular Recognition by Cytochrome P450cam.Disentangling ligand migration and heme pocket relaxation in cytochrome P450cam.Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury.Isotope effect studies on the cytochrome P450 enzymes.Cytochromes P450: their active-site structure and mechanism of oxidation.Bacterial cytochromes P-450.Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes.Conformational equilibrium of cytochrome P450 BM-3 complexed with N-palmitoylglycine: a replica exchange molecular dynamics study.Biotransformations of 2-methylisoborneol by camphor-degrading bacteria.Engineering the CYP101 system for in vivo oxidation of unnatural substrates.A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme.Putidaredoxin reductase-putidaredoxin-cytochrome p450cam triple fusion protein. Construction of a self-sufficient Escherichia coli catalytic system.Stereoselective hydroxylation of norcamphor by cytochrome P450cam. Experimental verification of molecular dynamics simulations.Cytochrome P450 Monooxygenase-Catalyzed Ring Opening of the Bicyclic Amine, Nortropine: An Experimental and DFT Computational StudyAccurate Description of Spin States and its Implications for Catalysis
P2860
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P2860
Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation
description
1991 nî lūn-bûn
@nan
1991 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի մարտին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Crystal structures of cytochro ...... P-450 substrate hydroxylation
@ast
Crystal structures of cytochro ...... P-450 substrate hydroxylation
@en
Crystal structures of cytochro ...... P-450 substrate hydroxylation
@nl
type
label
Crystal structures of cytochro ...... P-450 substrate hydroxylation
@ast
Crystal structures of cytochro ...... P-450 substrate hydroxylation
@en
Crystal structures of cytochro ...... P-450 substrate hydroxylation
@nl
prefLabel
Crystal structures of cytochro ...... P-450 substrate hydroxylation
@ast
Crystal structures of cytochro ...... P-450 substrate hydroxylation
@en
Crystal structures of cytochro ...... P-450 substrate hydroxylation
@nl
P356
P1433
P1476
Crystal structures of cytochro ...... P-450 substrate hydroxylation
@en
P2093
P304
P356
10.1021/BI00224A016
P407
P577
1991-03-12T00:00:00Z