Halogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues
about
Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acidStereospecific Formation of a Ternary Complex of (S)-α,β-Fluoromethylene-dATP with DNA Pol ββ,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31 P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA PolymerasesCombining a Clostridial enzyme exhibiting unusual active site plasticity with a remarkably facile sigmatropic rearrangement: rapid, stereocontrolled entry into densely functionalized fluorinated phosphonates for chemical biologyWeak Intermolecular Hydrogen Bonds with Fluorine: Detection and Implications for Enzymatic/Chemical Reactions, Chemical Properties, and Ligand/Protein Fluorine NMR Screening.On the observation of discrete fluorine NMR spectra for uridine 5'-β,γ-fluoromethylenetriphosphate diastereomers at basic pH.Quantum mechanical analysis of nonenzymatic nucleotidyl transfer reactions: kinetic and thermodynamic effects of β-γ bridging groups of dNTP substratesA Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated VariantSynthesis and sensing of bisphosphonophosphate alkyl monoesters: A novel class of compounds for the study of nucleoside 5'-triphosphate chemistry.Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of dTTPEffect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.5'-β,γ-CHF-ATP diastereomers: synthesis and fluorine-mediated selective binding by c-Src protein kinase.Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration.Chemical Stabilization of Unnatural Nucleotide Triphosphates for the in Vivo Expansion of the Genetic Alphabet.New Synthetic Methods for Phosphate Labeling.Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases.α-Azido bisphosphonates: synthesis and nucleotide analogues.DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.The effect of bisphosphonate acidity on the activity of a thymidylyltransferase.Influence of Alcohol β-Fluorination on Hydrogen-Bond Acidity of Conformationally Flexible Substrates.A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria.
P2860
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P2860
Halogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Halogenated β,γ-Methylene- and ...... the Fluoromethylene Analogues
@ast
Halogenated β,γ-Methylene- and ...... the Fluoromethylene Analogues
@en
Halogenated β,γ-Methylene- and ...... the Fluoromethylene Analogues
@nl
type
label
Halogenated β,γ-Methylene- and ...... the Fluoromethylene Analogues
@ast
Halogenated β,γ-Methylene- and ...... the Fluoromethylene Analogues
@en
Halogenated β,γ-Methylene- and ...... the Fluoromethylene Analogues
@nl
prefLabel
Halogenated β,γ-Methylene- and ...... the Fluoromethylene Analogues
@ast
Halogenated β,γ-Methylene- and ...... the Fluoromethylene Analogues
@en
Halogenated β,γ-Methylene- and ...... the Fluoromethylene Analogues
@nl
P2093
P2860
P356
P1476
Halogenated β,γ-Methylene- and ...... the Fluoromethylene Analogues
@en
P2093
Boris A Kashemirov
Charles E McKenna
Lars C Pedersen
Myron F Goodman
Samuel H Wilson
Thomas G Upton
Vinod K Batra
William A Beard
P2860
P304
P356
10.1021/JA909370K
P407
P577
2010-06-09T00:00:00Z