β,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31 P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
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On the observation of discrete fluorine NMR spectra for uridine 5'-β,γ-fluoromethylenetriphosphate diastereomers at basic pH.Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of dTTPEffect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution5'-β,γ-CHF-ATP diastereomers: synthesis and fluorine-mediated selective binding by c-Src protein kinase.Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration.Medicinal chemistry of fluorinated cyclic and acyclic nucleoside phosphonates.New Synthetic Methods for Phosphate Labeling.Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases.DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.
P2860
Q33761599-D1888EFD-CC52-4F59-946E-21904B096616Q36355109-3C8274F0-2029-4900-8AE0-D97021A37B1AQ36545114-8378593B-FA12-44DA-84B0-0630FB6AF237Q36870576-881094F2-9A74-4E4A-BDE1-9E514EC7DF7BQ36966447-9C9FC4F8-D3F6-46A0-B8C3-6EC60B9C863AQ37701454-1CBC600E-EA8F-46A9-B9CD-76871EBF7BA1Q38124799-F2F6939E-2958-4A3C-B3F8-72129ABE9AFEQ39263805-6439C2A0-D2B8-4879-AFA1-5728581F2016Q40189472-48EB3B8F-FF25-4349-9294-8EF9CDC74CA0Q46860273-9E2D709C-AAA9-464C-B819-91479AC75C48
P2860
β,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31 P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
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2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@ast
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@en
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@nl
type
label
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@ast
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@en
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@nl
prefLabel
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@ast
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@en
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@nl
P2093
P2860
P3181
P356
P1476
β,γ-CHF- and β,γ-CHCl-dGTP dia ...... cal probes for DNA polymerases
@en
P2093
Boris A Kashemirov
Charles E McKenna
Myron F Goodman
Valeria M Zakharova
Vinod K Batra
P2860
P304
P3181
P356
10.1021/JA300218X
P407
P577
2012-05-18T00:00:00Z