β,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31 P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases

β,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31 P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases

Item
http://www.wikidata.org/entity/Q27677876
On the observation of discrete fluorine NMR spectra for uridine 5'-β,γ-fluoromethylenetriphosphate diastereomers at basic pH.Two Scaffolds from Two Flips: (α,β)/(β,γ) CH2/NH "Met-Im" Analogues of dTTPEffect of β,γ-CHF- and β,γ-CHCl-dGTP halogen atom stereochemistry on the transition state of DNA polymerase β.Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution5'-β,γ-CHF-ATP diastereomers: synthesis and fluorine-mediated selective binding by c-Src protein kinase.Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration.Medicinal chemistry of fluorinated cyclic and acyclic nucleoside phosphonates.New Synthetic Methods for Phosphate Labeling.Remarkably Stereospecific Utilization of ATP α,β-Halomethylene Analogues by Protein Kinases.DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.
P2860

β,γ-CHF- and β,γ-CHCl-dGTP Diastereomers: Synthesis, Discrete 31 P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases

Item
http://www.wikidata.org/entity/Q27677876
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2012 nî lūn-bûn
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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
@zh-tw
2012年论文
@wuu
name
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@ast
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@en
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@nl
type
label
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@ast
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@en
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@nl
prefLabel
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@ast
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@en
β,γ-CHF- and β,γ-CHCl-dGTP Dia ...... cal Probes for DNA Polymerases
@nl
P1433
P1476
P2093
P2860
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932
P3181
P356
P1433
P1476
β,γ-CHF- and β,γ-CHCl-dGTP dia ...... cal probes for DNA polymerases
@en
P2093
P2860
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P5875
P698
P921
P932