Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
about
Novel transglutaminase-like peptidase and C2 domains elucidate the structure, biogenesis and evolution of the ciliary compartmentStructural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.The same pocket in menin binds both MLL and JUND but has opposite effects on transcriptionHigh-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein InteractionProperty Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemiaThe role of HTS in drug discovery at the University of Michigan.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Challenges and opportunities in targeting the menin-MLL interaction.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Impaired transforming growth factor-β (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1 (MEN1).Variable clinical expression in patients with a germline MEN1 disease gene mutation: clues to a genotype-phenotype correlation.A new double substitution mutation in the MEN1 gene: a limited penetrance and a specific phenotype.The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.Menin as a hub controlling mixed lineage leukemia.The many facets of MLL1 regulation.Current understanding of the molecular biology of pancreatic neuroendocrine tumors.Menin: a scaffold protein that controls gene expression and cell signaling.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Twenty years of menin: emerging opportunities for restoration of transcription in MEN1.SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes.KAT8 Regulates Androgen Signaling in Prostate Cancer Cells.Menin localization in cell membrane compartmentDetection of disordered regions in globular proteins using ¹³C-detected NMR.PepSite: prediction of peptide-binding sites from protein surfaces.Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.Trithorax and polycomb cooperation in MLL fusion acute leukemia.Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).Novel mutation 928G>C of MEN1 gene in a familial multiple endocrine neoplasia type 1 case (MEN1) with co-existence of insulinoma and glucagonoma.Pharmacologic Inhibition of the Menin-MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma.The future: genetics advances in MEN1 therapeutic approaches and management strategies.Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy.Establishing a model organism: a report from the first annual Nematostella meeting.
P2860
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P2860
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein
@nl
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
@ast
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
@en
type
label
Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein
@nl
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
@ast
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
@en
prefLabel
Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein
@nl
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
@ast
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
@en
P2093
P2860
P921
P356
P1476
Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
@en
P2093
Gireesh Reddy
Jolanta Grembecka
Marcelo J Murai
Tomasz Cierpicki
P2860
P304
31742-31748
P356
10.1074/JBC.M111.258186
P407
P577
2011-07-13T00:00:00Z