Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
about
Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesPerspectives on electrostatics and conformational motions in enzyme catalysisDesign of activated serine–containing catalytic triads with atomic-level accuracyUncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase.Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site.Enzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase.Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site.Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase.Ground state destabilization from a positioned general base in the ketosteroid isomerase active site.Mechanistic Imperatives for Deprotonation of Carbon Catalyzed by Triosephosphate Isomerase: Enzyme-Activation by Phosphite Dianion.Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site.Acceleration of an aromatic Claisen rearrangement via a designed spiroligozyme catalyst that mimics the ketosteroid isomerase catalytic dyad.Specificity in transition state binding: the Pauling model revisited.Electric Fields and Enzyme Catalysis.
P2860
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P2860
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
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2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
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2011年论文
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name
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
@ast
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
@en
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
@nl
type
label
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
@ast
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
@en
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
@nl
prefLabel
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
@ast
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
@en
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
@nl
P2093
P2860
P356
P1476
Evaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid Isomerase
@en
P2093
Ana Gonzalez
Jason P Schwans
Yingssu Tsai
P2860
P304
P356
10.1021/JA208050T
P407
P577
2011-12-21T00:00:00Z