Dissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion hole
about
Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymesMutation at a Strictly Conserved, Active Site Tyrosine in the Copper Amine Oxidase Leads to Uncontrolled Oxygenase ActivityEvaluating the Catalytic Contribution from the Oxyanion Hole in Ketosteroid IsomeraseRescue of deleterious mutations by the compensatory Y30F mutation in ketosteroid isomeraseQuantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active siteUse of anion-aromatic interactions to position the general base in the ketosteroid isomerase active siteConvergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase.Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase.Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site.Kemp Eliminase Activity of Ketosteroid Isomerase.Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization.Water in the active site of ketosteroid isomerase.Intrigues and intricacies of the biosynthetic pathways for the enzymatic quinocofactors: PQQ, TTQ, CTQ, TPQ, and LTQExtreme electric fields power catalysis in the active site of ketosteroid isomeraseEnzyme architecture: deconstruction of the enzyme-activating phosphodianion interactions of orotidine 5'-monophosphate decarboxylase.Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site.Contribution of active site glutamine to rate enhancement in ubiquitin C-terminal hydrolases.Site-specific measurement of water dynamics in the substrate pocket of ketosteroid isomerase using time-resolved vibrational spectroscopyDissecting Proton Delocalization in an Enzyme's Hydrogen Bond Network with Unnatural Amino Acids.Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase.BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase"Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site.Membrane protein folding: how important are hydrogen bonds?Specificity in transition state binding: the Pauling model revisited.Computational enzyme design.Prediction of distal residue participation in enzyme catalysis.Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.Calculation of vibrational shifts of nitrile probes in the active site of ketosteroid isomerase upon ligand binding.Impact of mutation on proton transfer reactions in ketosteroid isomerase: insights from molecular dynamics simulationsQM/MM modelling of ketosteroid isomerase reactivity indicates that active site closure is integral to catalysis.BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".Effect of superalkali substituents on the strengths and properties of hydrogen and halogen bonds.
P2860
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P2860
Dissecting the paradoxical effects of hydrogen bond mutations in the ketosteroid isomerase oxyanion hole
description
2010 nî lūn-bûn
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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
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2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
Dissecting the paradoxical eff ...... teroid isomerase oxyanion hole
@ast
Dissecting the paradoxical eff ...... teroid isomerase oxyanion hole
@en
Dissecting the paradoxical eff ...... teroid isomerase oxyanion hole
@nl
type
label
Dissecting the paradoxical eff ...... teroid isomerase oxyanion hole
@ast
Dissecting the paradoxical eff ...... teroid isomerase oxyanion hole
@en
Dissecting the paradoxical eff ...... teroid isomerase oxyanion hole
@nl
prefLabel
Dissecting the paradoxical eff ...... teroid isomerase oxyanion hole
@ast
Dissecting the paradoxical eff ...... teroid isomerase oxyanion hole
@en
Dissecting the paradoxical eff ...... teroid isomerase oxyanion hole
@nl
P2093
P2860
P356
P1476
Dissecting the paradoxical eff ...... teroid isomerase oxyanion hole
@en
P2093
Daniel A Kraut
Paul A Sigala
Timothy D Fenn
P2860
P304
P356
10.1073/PNAS.0911168107
P407
P577
2010-02-02T00:00:00Z