Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange
about
Human leukocyte Antigen-DM polymorphisms in autoimmune diseasesA step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cellsThe Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular DynamicsHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismCrystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide SelectionDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IISusceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with PeptideA structural and molecular dynamics approach to understanding the peptide-receptive transition state of MHC-I molecules.Selector function of MHC I molecules is determined by protein plasticityPeptide modulation of class I major histocompatibility complex protein molecular flexibility and the implications for immune recognition.Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates.HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis.Defining molecular signature of pro-immunogenic radiotherapy targets in human prostate cancer cells.Structural and dynamical insights on HLA-DR2 complexes that confer susceptibility to multiple sclerosis in Sardinia: a molecular dynamics simulation studyHLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM.HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-livesThermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal.Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.HLA-DM: arbiter conformationis.Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough.Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes.HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange.HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization.Proofreading of Peptide-MHC Complexes through Dynamic Multivalent Interactions.Peptidomic analysis of type 1 diabetes associated HLA-DQ molecules and the impact of HLA-DM on peptide repertoire editing.Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation.A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination.MHC class II complexes sample intermediate states along the peptide exchange pathway.Single-molecule motions of MHC class II rely on bound peptides.A Peptide/MHCII conformer generated in the presence of exchange peptide is substrate for HLA-DM editing.Efficient estimation of binding free energies between peptides and an MHC class II molecule using coarse-grained molecular dynamics simulations with a weighted histogram analysis method.Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides.The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated SignalingPeptide Secondary Structures as Molecular Switches
P2860
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P2860
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange
description
2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Conformational lability in the ...... ptibility and peptide exchange
@ast
Conformational lability in the ...... ptibility and peptide exchange
@en
Conformational lability in the ...... ptibility and peptide exchange
@nl
type
label
Conformational lability in the ...... ptibility and peptide exchange
@ast
Conformational lability in the ...... ptibility and peptide exchange
@en
Conformational lability in the ...... ptibility and peptide exchange
@nl
prefLabel
Conformational lability in the ...... ptibility and peptide exchange
@ast
Conformational lability in the ...... ptibility and peptide exchange
@en
Conformational lability in the ...... ptibility and peptide exchange
@nl
P2093
P2860
P3181
P356
P1476
Conformational lability in the ...... ptibility and peptide exchange
@en
P2093
Corrie A Painter
James E Evans
Katherine A Kellersberger
Lawrence J Stern
Maria P Negroni
P2860
P304
19329-19334
P3181
P356
10.1073/PNAS.1108074108
P407
P577
2011-11-14T00:00:00Z