Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
about
Ubiquitination of human leukocyte antigen (HLA)-DM by different membrane-associated RING-CH (MARCH) protein family E3 ligases targets different endocytic pathwaysMapping the HLA-DO/HLA-DM complex by FRET and mutagenesisSmall molecules that enhance the catalytic efficiency of HLA-DMHuman leukocyte Antigen-DM polymorphisms in autoimmune diseasesAn MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient miceThe Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular DynamicsHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismCrystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide SelectionConformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchangeDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IISusceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with PeptideAchieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expressionH2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 miceNegative regulation by HLA-DO of MHC class II-restricted antigen processingThe impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II moleculesComprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates.Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptideIdentification of the transcriptional response of human intestinal mucosa to Lactobacillus plantarum WCFS1 in vivo.HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.Evolution of the mammalian MHC: natural selection, recombination, and convergent evolution.Mechanisms of antigen presentation.Phagocytic antigen processing and effects of microbial products on antigen processing and T-cell responses.Major histocompatibility complex class II antigen presentation in Hodgkin's disease.Peptide exchange in MHC molecules.Individual hydrogen bonds play a critical role in MHC class II: peptide interactions: implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchange.The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation.Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes.The kinetic basis of peptide exchange catalysis by HLA-DMCutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes.Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DMCTCF controls expression and chromatin architecture of the human major histocompatibility complex class II locus.Phagocytic processing of antigens for presentation by class II major histocompatibility complex molecules.A pH-sensitive histidine residue as control element for ligand release from HLA-DR moleculesHLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.Binding interactions between peptides and proteins of the class II major histocompatibility complex.Functional HLA-DM on the surface of B cells and immature dendritic cells.The melting pot of the MHC II peptidomeThe convergent roles of tapasin and HLA-DM in antigen presentation.HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.
P2860
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P2860
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
description
1996 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Science
@fr
artículu científicu espublizáu en 1996
@ast
im Oktober 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/10/25)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/10/25)
@nl
наукова стаття, опублікована в жовтні 1996
@uk
name
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
@ast
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
@en
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
@nl
type
label
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
@ast
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
@en
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
@nl
prefLabel
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
@ast
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
@en
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
@nl
P3181
P1433
P1476
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM
@en
P2093
P304
P3181
P356
10.1126/SCIENCE.274.5287.618
P407
P577
1996-10-01T00:00:00Z