HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives
about
Human leukocyte Antigen-DM polymorphisms in autoimmune diseasesA step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cellsMHC Class II Auto-Antigen Presentation is UnconventionalSusceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with PeptideAn unstable Th epitope of P. falciparum fosters central memory T cells and anti-CS antibody responses.Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.The melting pot of the MHC II peptidomeEvaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.A Simple Proteomics-Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen: Application to the CD4 T Cell Response against Human Herpesvirus 6BThe Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM SensitivityThermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal.The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilingsHLA-DO and Its Role in MHC Class II Antigen Presentation.HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange.HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization.Determinants of immunodominance for CD4 T cells.Transcriptional profiling and co-expression network analysis identifies potential biomarkers to differentiate chronic hepatitis B and the caused cirrhosis.Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.Peptidomic analysis of type 1 diabetes associated HLA-DQ molecules and the impact of HLA-DM on peptide repertoire editing.A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination.Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes.The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling.Distorted Immunodominance by Linker Sequences or other Epitopes from a Second Protein Antigen During Antigen-Processing.Protein-Specific Features Associated with Variability in Human Antibody Responses to Plasmodium falciparum Malaria Antigens.Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components.Predicting HLA CD4 Immunogenicity in Human Populations.
P2860
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P2860
HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives
description
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name
HLA-DM constrains epitope sele ...... ger HLA-DM-mediated half-lives
@ast
HLA-DM constrains epitope sele ...... ger HLA-DM-mediated half-lives
@en
type
label
HLA-DM constrains epitope sele ...... ger HLA-DM-mediated half-lives
@ast
HLA-DM constrains epitope sele ...... ger HLA-DM-mediated half-lives
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prefLabel
HLA-DM constrains epitope sele ...... ger HLA-DM-mediated half-lives
@ast
HLA-DM constrains epitope sele ...... ger HLA-DM-mediated half-lives
@en
P2093
P2860
P356
P1476
HLA-DM constrains epitope sele ...... ger HLA-DM-mediated half-lives
@en
P2093
J Mauricio Calvo-Calle
Lawrence J Stern
Liusong Yin
Omar Dominguez-Amorocho
P2860
P304
P356
10.4049/JIMMUNOL.1200626
P407
P577
2012-09-10T00:00:00Z