[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding
about
Wnt/beta-catenin signaling and small molecule inhibitorsFlavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapiesStructural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Structural Implications for Selective Targeting of PARPs.An unexpected role for a Wnt-inhibitor: Dickkopf-1 triggers a novel cancer survival mechanism through modulation of aldehyde-dehydrogenase-1 activity.New insights into the regulation of Axin function in canonical Wnt signaling pathway.PARP inhibitors in cancer therapy: an update.Tankyrases as drug targets.Tankyrases: structure, function and therapeutic implications in cancer.Recent advances in the structure-based rational design of TNKSIs.The impact of binding thermodynamics on medicinal chemistry optimizations.Targeting Tankyrase to Fight WNT-dependent Tumours.Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells.Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases.Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors.Small Molecule Microarray Based Discovery of PARP14 Inhibitors.Small Molecule Microarray Based Discovery of PARP14 Inhibitors
P2860
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P2860
[1,2,4]triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding
description
2012 nî lūn-bûn
@nan
2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
[1,2,4]triazol-3-ylsulfanylmet ...... novel adenosine pocket binding
@ast
[1,2,4]triazol-3-ylsulfanylmet ...... novel adenosine pocket binding
@en
[1,2,4]triazol-3-ylsulfanylmet ...... novel adenosine pocket binding
@nl
type
label
[1,2,4]triazol-3-ylsulfanylmet ...... novel adenosine pocket binding
@ast
[1,2,4]triazol-3-ylsulfanylmet ...... novel adenosine pocket binding
@en
[1,2,4]triazol-3-ylsulfanylmet ...... novel adenosine pocket binding
@nl
prefLabel
[1,2,4]triazol-3-ylsulfanylmet ...... novel adenosine pocket binding
@ast
[1,2,4]triazol-3-ylsulfanylmet ...... novel adenosine pocket binding
@en
[1,2,4]triazol-3-ylsulfanylmet ...... novel adenosine pocket binding
@nl
P2093
P356
P1476
[1,2,4]triazol-3-ylsulfanylmet ...... novel adenosine pocket binding
@en
P2093
Atwood Cheung
Bailin Zhang
Christina A Kirby
Donovan N Chin
Hong Cheng
Jutta Blank
Michael D Shultz
Olga Charlat
P304
P356
10.1021/JM2011222
P407
P577
2012-02-09T00:00:00Z