Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling
about
Large-scale production and protein engineering of G protein-coupled receptors for structural studiesStructural basis for Smoothened receptor modulation and chemoresistance to anticancer drugsStructural basis of Smoothened regulation by its extracellular domainsSmoothened goes molecular: new pieces in the hedgehog signaling puzzleCrystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligandSmoothened Regulation: A Tale of Two Signals.The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.Functional Divergence in the Role of N-Linked Glycosylation in Smoothened SignalingSynthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail.The Hedgehog pathway: role in cell differentiation, polarity and proliferationStructure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled.Smoothened regulation in response to Hedgehog stimulation.G-protein-coupled receptors, Hedgehog signaling and primary cilia.Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies.Regulation of the oncoprotein Smoothened by small molecules.Mutational analysis of the Aspergillus ambient pH receptor PalH underscores its potential as a target for antifungal compounds.Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.Wnt and Hedgehog Signaling Regulate the Differentiation of F9 Cells into Extraembryonic Endoderm.The role of the Hedgehog signaling pathway in cancer: A comprehensive review.Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates.A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor
P2860
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P2860
Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structural insights into the r ...... domain in Hedgehog signalling
@ast
Structural insights into the r ...... domain in Hedgehog signalling
@en
Structural insights into the r ...... domain in Hedgehog signalling
@nl
type
label
Structural insights into the r ...... domain in Hedgehog signalling
@ast
Structural insights into the r ...... domain in Hedgehog signalling
@en
Structural insights into the r ...... domain in Hedgehog signalling
@nl
prefLabel
Structural insights into the r ...... domain in Hedgehog signalling
@ast
Structural insights into the r ...... domain in Hedgehog signalling
@en
Structural insights into the r ...... domain in Hedgehog signalling
@nl
P2093
P2860
P3181
P356
P1476
Structural insights into the r ...... domain in Hedgehog signalling
@en
P2093
Candace E Carroll
Christy R R Grace
Cristina D Guibao
Ho-Jin Lee
Rajashree Rana
Stacey K Ogden
Suresh Marada
P2860
P2888
P3181
P356
10.1038/NCOMMS3965
P407
P50
P577
2013-01-01T00:00:00Z
P5875
P6179
1000941415