Structural basis for activity regulation of MLL family methyltransferases
about
Targeted Disruption of the Interaction Between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase ComplexesMenin enhances c-Myc-mediated transcription to promote cancer progressionH3K4 Methyltransferase Activity Is Required for MLL4 Protein Stability.Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.Structural analysis of an active fungal PRC2.MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.Role of RbBP5 and H3K4me3 in the vicinity of Snail transcription start site during epithelial-mesenchymal transition in prostate cancer cell.An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.Inhibitors of Protein Methyltransferases and Demethylases.The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer.Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes.Allosteric control of mammalian DNA methyltransferases - a new regulatory paradigm.Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complexMLL5 (KMT2E): structure, function, and clinical relevance.Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family.Writing, erasing and reading histone lysine methylations.Computational characterization of substrate and product specificities, and functionality of S-adenosylmethionine binding pocket in histone lysine methyltransferases from Arabidopsis, rice and maize.WD40 repeat domain proteins: a novel target class?Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer.Protein 19F-labeling using transglutaminase for the NMR study of intermolecular interactions.Moonlighting with WDR5: A Cellular Multitasker.WDR5 in porcine preimplantation embryos: expression, regulation of epigenetic modifications and requirement for early development†.Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin.
P2860
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P2860
Structural basis for activity regulation of MLL family methyltransferases
description
2016 nî lūn-bûn
@nan
2016 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Structural basis for activity regulation of MLL family methyltransferases
@ast
Structural basis for activity regulation of MLL family methyltransferases
@en
Structural basis for activity regulation of MLL family methyltransferases
@nl
type
label
Structural basis for activity regulation of MLL family methyltransferases
@ast
Structural basis for activity regulation of MLL family methyltransferases
@en
Structural basis for activity regulation of MLL family methyltransferases
@nl
prefLabel
Structural basis for activity regulation of MLL family methyltransferases
@ast
Structural basis for activity regulation of MLL family methyltransferases
@en
Structural basis for activity regulation of MLL family methyltransferases
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structural basis for activity regulation of MLL family methyltransferases
@en
P2093
Changlin Tian
Dangsheng Li
Jian Zhang
Jianming Han
P2860
P2888
P304
P3181
P356
10.1038/NATURE16952
P407
P577
2016-02-25T00:00:00Z
P5875
P6179
1046108534