Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2 - Wikidata - wikimedia - TriplyDB

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

http://www.wikidata.org/entity/Q27704279

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Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib.Molecular dynamics simulations and modelling of the residue interaction networks in the BRAF kinase complexes with small molecule inhibitors: probing the allosteric effects of ligand-induced kinase dimerization and paradoxical activation.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool.Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis.Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes.Overcoming resistance to HER2 inhibitors through state-specific kinase binding.An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling.Drugging RAS: Know the enemy.Switching Aurora-A kinase on and off at an allosteric site.Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types.Deletion Mutations Keep Kinase Inhibitors in the Loop.New somatic BRAF splicing mutation in Langerhans cell histiocytosis.Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis.Ensemble-based modeling and rigidity decomposition of allosteric interaction networks and communication pathways in cyclin-dependent kinases: Differentiating kinase clients of the Hsp90-Cdc37 chaperone.Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains.Targeting the Raf kinases in human cancer: the Raf dimer dilemma.KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer.New perspectives for targeting RAF kinase in human cancer.Atropisomerism in medicinal chemistry: challenges and opportunities.Network-based modelling and percolation analysis of conformational dynamics and activation in the CDK2 and CDK4 proteins: dynamic and energetic polarization of the kinase lobes may determine divergence of the regulatory mechanisms.Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.Heterogeneous effects of M-CSF isoforms on the progression of MLL-AF9 leukemia.A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.Accelerating Discovery of Functional Mutant Alleles in Cancer.Increased autophagy blocks HER2-mediated breast tumorigenesis.Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties.Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells.BRAF activating mutations involving the β3-αC loop in V600E-negative anaplastic pleomorphic xanthoastrocytoma.The dimer-dependent catalytic activity of RAF family kinases is revealed through characterizing their oncogenic mutants

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P2860

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

http://www.wikidata.org/entity/Q27704279

description

2016 nî lūn-bûn

@nan

2016 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2016 թվականի ապրիլին հրատարակված գիտական հոդված

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

@zh-hk

2016年論文

@zh-mo

2016年論文

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2016年论文

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name

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

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Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

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Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

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type

label

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

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Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

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Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

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prefLabel

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

@ast

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

@en

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

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J.CCELL.2016.02.010

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P1476

Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2

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Andrey S Shaw

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Ayşegül Özen

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Christine Yu

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Daniel M Whalen

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Gabriele Schaefer

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Georgia Hatzivassiliou

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Ivana Yen

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JianPing Yin

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John D Mayfield

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Kyung Song

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477-93

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scholarly article

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10.1016/J.CCELL.2016.02.010

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29

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Charles Eigenbrot

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Juliann Chmielecki

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2016-04-11T00:00:00Z

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