Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis
about
FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibitionAnalysing the visible conformational substates of the FK506-binding protein FKBP12Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiaeHmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomeraseA novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus.The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target proteinBinding specificity of Escherichia coli trigger factor.Calcineurin is essential for survival during membrane stress in Candida albicans.Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei.Assessing the chemical accuracy of protein structures via peptide acidity.In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection.Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.Basic surface features of nuclear FKBPs facilitate chromatin binding.Cloud computing approaches for prediction of ligand binding poses and pathways.Calcineurin is required for virulence of Cryptococcus neoformans.Structure comparison of native and mutant human recombinant FKBP12 complexes with the immunosuppressant drug FK506 (tacrolimus).
P2860
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P2860
Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis
description
1993 nî lūn-bûn
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1993 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Improved calcineurin inhibitio ...... raphic and functional analysis
@ast
Improved calcineurin inhibitio ...... raphic and functional analysis
@en
Improved calcineurin inhibitio ...... raphic and functional analysis
@nl
type
label
Improved calcineurin inhibitio ...... raphic and functional analysis
@ast
Improved calcineurin inhibitio ...... raphic and functional analysis
@en
Improved calcineurin inhibitio ...... raphic and functional analysis
@nl
prefLabel
Improved calcineurin inhibitio ...... raphic and functional analysis
@ast
Improved calcineurin inhibitio ...... raphic and functional analysis
@en
Improved calcineurin inhibitio ...... raphic and functional analysis
@nl
P2093
P1476
Improved calcineurin inhibitio ...... raphic and functional analysis
@en
P2093
P304
P407
P577
1993-04-15T00:00:00Z