Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
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The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesisInteraction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506Light controls growth and development via a conserved pathway in the fungal kingdomCNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90.FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene.Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiaevph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomeraseSaccharomyces cerevisiae FKBP12 binds Arabidopsis thaliana TOR and its expression in plants leads to rapamycin susceptibility.Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase.All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae.Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformansCalcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformansThe NAF domain defines a novel protein-protein interaction module conserved in Ca2+-regulated kinases.Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TORTwo cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformansThe immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target proteinCalcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl IsomerizationCalcineurin Targets Involved in Stress Survival and Fungal VirulenceTrypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms.Functional analysis of BcBem1 and its interaction partners in Botrytis cinerea: impact on differentiation and virulenceRapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans.A novel multi-functional chloroplast protein: identification of a 40 kDa immunophilin-like protein located in the thylakoid lumenPheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans.Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurinPharmGKB summary: cyclosporine and tacrolimus pathwaysCharacterization of an Nmr homolog that modulates GATA factor-mediated nitrogen metabolite repression in Cryptococcus neoformans.The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans.Rapamycin inhibits vascular smooth muscle cell migration.Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi.Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals.CYP1, a hypovirus-regulated cyclophilin, is required for virulence in the chestnut blight fungus.Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters.TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19.Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.
P2860
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P2860
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
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1994年學術文章
@zh-hant
name
Immunophilins interact with ca ...... ous immunosuppressive ligands.
@en
type
label
Immunophilins interact with ca ...... ous immunosuppressive ligands.
@en
prefLabel
Immunophilins interact with ca ...... ous immunosuppressive ligands.
@en
P2093
P2860
P1433
P1476
Immunophilins interact with ca ...... ous immunosuppressive ligands.
@en
P2093
P2860
P304
P407
P577
1994-12-01T00:00:00Z