The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein
about
Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed alpha-helixComponents of the calcium-calcineurin signaling pathway in fungal cells and their potential as antifungal targetsAntifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug actionSynergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformansCalcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformansRapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TORCryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcomeCalcineurin governs thermotolerance and virulence of Cryptococcus gattii.Novel paradigms for drug discovery: computational multitarget screeningRapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.Paradoxical roles of alveolar macrophages in the host response to Cryptococcus neoformans.Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurinSignal transduction cascades regulating fungal development and virulence.Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the hostCalcineurin is essential for survival during membrane stress in Candida albicans.DNA mutations mediate microevolution between host-adapted forms of the pathogenic fungus Cryptococcus neoformans.Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei.Donor transmission of Cryptococcus neoformans presenting late after renal transplantationIn vitro interactions between tacrolimus and azoles against Candida albicans determined by different methodsSignaling cascades as drug targets in model and pathogenic fungi.In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.Antifungal adjuvants: Preserving and extending the antifungal arsenalIn vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformansCryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.Cryptococcal infection in non-HIV immunosuppressed patients - Three case reports in a nephrology setting.Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans.New Horizons in Antifungal Therapy.
P2860
Q27636960-9E03B457-1292-4E1C-9FCE-1994BE51414DQ28080558-D9065E96-F2E3-4525-BA82-1FCA4BEA0275Q28343624-CCE187AF-4A31-4FB9-86B7-502E00102513Q28343929-84686856-B283-423D-BC9A-F2B795FDC5D5Q28354724-9C4229BE-8321-4A77-8AF9-A52544A4D276Q28361576-5D67E69A-3489-4B3D-A3AE-2CB7843EE3C0Q28366062-AC640D11-0432-4BC4-AAFD-8D1CB4086A54Q30536858-4175A4D0-7D96-4BEF-9D45-F909FBF877C4Q30662767-BDD0BE94-AE90-4947-8DF0-2CA744F198CFQ33651856-204F31EB-A5CC-4574-A8D4-DF1A0AAAEA1EQ33673568-38994DA9-A5CB-451C-B3DE-DDF81E7A04AEQ33978506-CE9A0DCF-1CE6-4FBD-ABAA-FC0794915406Q34010291-89815485-7F48-4827-854D-B10A06A58C07Q34055174-40AF097E-0434-4D61-A3BA-1FBF17EC119CQ34085830-68E1AAC9-F4C9-4920-BABC-4C548F3135CCQ34440643-479217EA-CE0C-4DDA-B47A-2C206086226AQ34735206-164FB6B5-3523-42B0-B1F3-0323E9DC0DEAQ35608463-7D0B51CA-8F80-425B-81D8-0F6BD608B398Q36425093-6FCD8025-DCC2-471B-A71B-7DC57F3D2FD3Q37230044-9E76EA97-CB4D-4A62-8A71-832A87915530Q37625139-7CFDAACE-6198-456F-B6E3-A3F78C103055Q37705308-03725F7C-B06B-4451-8CD3-49FD6C0E6BD0Q37734474-F63D7F4D-DF77-4B20-B58A-2CAA977646A4Q38871364-8965237C-230F-4827-BE8F-EDE23791574EQ39514274-C9F06565-9F64-40D0-8E6B-79E870759853Q40771289-55CC61F7-2CE1-4522-A8CB-918210E51497Q41889615-EC5E1B5E-13A1-469A-A5AE-2E72FC67D08BQ41969837-7FFC245D-1FCD-4479-B420-CE65962EBAB5Q47300999-82BBC438-B5FB-479B-A3C5-FE192E1CC54DQ48149179-83813189-B3B4-42DB-967D-A0E07EF5FB45
P2860
The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The immunosuppressant FK506 an ...... ion of a common target protein
@ast
The immunosuppressant FK506 an ...... ion of a common target protein
@en
The immunosuppressant FK506 an ...... ion of a common target protein
@nl
type
label
The immunosuppressant FK506 an ...... ion of a common target protein
@ast
The immunosuppressant FK506 an ...... ion of a common target protein
@en
The immunosuppressant FK506 an ...... ion of a common target protein
@nl
prefLabel
The immunosuppressant FK506 an ...... ion of a common target protein
@ast
The immunosuppressant FK506 an ...... ion of a common target protein
@en
The immunosuppressant FK506 an ...... ion of a common target protein
@nl
P2093
P2860
P1476
The immunosuppressant FK506 an ...... ion of a common target protein
@en
P2093
P2860
P304
P407
P577
1997-01-01T00:00:00Z