Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors
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Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolutionLysosomal cysteine proteases: facts and opportunities.Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegmentStructure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteasesStefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleftNovel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compoundsStructural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoniCrystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptideThe crystal structure of human cathepsin L complexed with E-64Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates.Epoxysuccinyl peptide-derived affinity labels for cathepsin B.How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamicsSubclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.Structure-based development of specific inhibitors for individual cathepsins and their medical applications.Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors.Cysteine proteases and cell differentiation: excystment of the ciliated protist Sterkiella histriomuscorum.Autocatalytic processing of procathepsin B is triggered by proenzyme activityTargeting Cathepsin B for Cancer Therapies.Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides.The proteasome: a macromolecular assembly designed to confine proteolysis to a nanocompartment.Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges.Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling.Cathepsin B Inhibitors: Combining Dipeptide Nitriles with an Occluding Loop Recognition Element by Click Chemistry.A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.Molecular dynamics studies of caspase-3.Accumulation of sialic acid in endocytic compartments interferes with the formation of mature lysosomes. Impaired proteolytic processing of cathepsin B in fibroblasts of patients with lysosomal sialic acid storage disease.Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease.Foot-and-mouth disease virus leader proteinase: structural insights into the mechanism of intermolecular cleavageSorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells.Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptidesS2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B.LeView: automatic and interactive generation of 2D diagrams for biomacromolecule/ligand interactionsStructural determinants of specificity in the cysteine protease cruzain.Crystal structure of human cathepsin S.Optimization of peptidyl allyl sulfones as clan CA cysteine protease inhibitors.Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design.CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells.Vito Turk--30 years of research on cysteine proteases and their inhibitors.
P2860
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P2860
Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Crystal structure of cathepsin ...... cific epoxysuccinyl inhibitors
@ast
Crystal structure of cathepsin ...... cific epoxysuccinyl inhibitors
@en
Crystal structure of cathepsin ...... cific epoxysuccinyl inhibitors
@nl
type
label
Crystal structure of cathepsin ...... cific epoxysuccinyl inhibitors
@ast
Crystal structure of cathepsin ...... cific epoxysuccinyl inhibitors
@en
Crystal structure of cathepsin ...... cific epoxysuccinyl inhibitors
@nl
prefLabel
Crystal structure of cathepsin ...... cific epoxysuccinyl inhibitors
@ast
Crystal structure of cathepsin ...... cific epoxysuccinyl inhibitors
@en
Crystal structure of cathepsin ...... cific epoxysuccinyl inhibitors
@nl
P2093
P356
P1433
P1476
Crystal structure of cathepsin ...... cific epoxysuccinyl inhibitors
@en
P2093
M Podobnik
N Katunuma
P304
P356
10.1021/BI00014A037
P407
P577
1995-04-11T00:00:00Z