CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells.
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Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsCathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateCathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasmCathepsin B in antigen-presenting cells controls mediators of the Th1 immune response during Leishmania major infectionImaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium CompoundAnalysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved ProteasesCystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation.Regulation of TGF-β1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C.Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.Infection of XC cells by MLVs and Ebola virus is endosome-dependent but acidification-independent.Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L.Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity.Bone microenvironment modulates expression and activity of cathepsin B in prostate cancer.Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's diseaseChemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D-Bax activation loop.Human monocytes augment invasiveness and proteolytic activity of inflammatory breast cancer.Targeting Cathepsin B for Cancer Therapies.A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasitesCathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles.Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B.UVA causes dual inactivation of cathepsin B and L underlying lysosomal dysfunction in human dermal fibroblasts.Three-dimensional cultures modeling premalignant progression of human breast epithelial cells: role of cysteine cathepsins.CA-074Me protection against anthrax lethal toxin.Curcumin targets the TFEB-lysosome pathway for induction of autophagy.Cathepsin L in metastatic bone disease: therapeutic implications.Cathepsin-B and cathepsin-L expression levels do not correlate with sensitivity of tumour cells to TNF-alpha-mediated apoptosis.Measurement and Mathematical Characterization of Cell-Level Pharmacokinetics of Antibody-Drug Conjugates: A Case Study with Trastuzumab-vc-MMAE.Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells.Identification and synthesis of a unique thiocarbazate cathepsin L inhibitorHypoxia causes autophagic stress and derangement of metabolic adaptation in a cell model of amyotrophic lateral sclerosis.Induction of cell death in neuroblastoma by inhibition of cathepsins B and L.Cathepsin S supports acid-independent infection by some reoviruses.Oxygen-glucose deprivation (OGD) and interleukin-1 (IL-1) differentially modulate cathepsin B/L mediated generation of neuroprotective perlecan LG3 by neurons.Host cell cathepsins potentiate Moloney murine leukemia virus infection.Iowa Mutant Apolipoprotein A-I (ApoA-IIowa) Fibrils Target Lysosomes.Cathepsin L is involved in proteolytic processing of the Hendra virus fusion protein.Insulin-like growth factor II receptor-mediated intracellular retention of cathepsin B is essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus.Multiple Cathepsins Promote Pro-IL-1β Synthesis and NLRP3-Mediated IL-1β ActivationAlum Activates the Bovine NLRP3 Inflammasome.
P2860
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P2860
CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
CA-074, but not its methyl est ...... thepsin B within living cells.
@en
CA-074, but not its methyl est ...... thepsin B within living cells.
@nl
type
label
CA-074, but not its methyl est ...... thepsin B within living cells.
@en
CA-074, but not its methyl est ...... thepsin B within living cells.
@nl
prefLabel
CA-074, but not its methyl est ...... thepsin B within living cells.
@en
CA-074, but not its methyl est ...... thepsin B within living cells.
@nl
P2860
P356
P1433
P1476
CA-074, but not its methyl est ...... thepsin B within living cells.
@en
P2093
Lukas Mach
Metwally Montaser
P2860
P304
P356
10.1515/BC.2002.147
P577
2002-07-01T00:00:00Z