A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease
about
Current and potential treatments for ubiquitous but neglected herpesvirus infectionsComplex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal formThe structure of aspartyl dipeptidase reveals a unique fold with a Ser-His-Glu catalytic triadSubstrate Modulation of Enzyme Activity in the Herpesvirus Protease FamilyStructural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitorsBroad-Spectrum Allosteric Inhibition of Herpesvirus ProteasesCrystal structure of varicella-zoster virus proteaseConserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus proteaseUnconventional serine proteases: variations on the catalytic Ser/His/Asp triad configurationDimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine ProteaseExtensive subunit contacts underpin herpesvirus capsid stability and interior-to-exterior allostery.Overview of protein structural and functional folds.A structural tree for proteins containing 3beta-corners.The Bacillus subtilis signaling protein SpoIVB defines a new family of serine peptidasesThe herpesvirus proteases as targets for antiviral chemotherapy.Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.Inhibition of a viral enzyme by a small-molecule dimer disruptor.Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity.Recent strategies in the development of new human cytomegalovirus inhibitors.Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions.Non-nucleoside inhibitors of herpesviruses.Functional domains of the HK97 capsid maturation protease and the mechanisms of protein encapsidation.Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain.The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).Identification of the sites of interaction between the scaffold and outer shell in herpes simplex virus-1 capsids by difference electron imaging.An unexpected structural relationship between integral membrane phosphatases and soluble haloperoxidases.Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymeraseAnti-herpesvirus agents: a patent and literature review (2003 to present).Influenza virus RNA polymerase PA subunit is a novel serine protease with Ser624 at the active site.Active site mutants of human herpesvirus-6 proteinase.Protease inhibitors as antiviral agents.Expression and characterization of recombinant murine cytomegalovirus protease.Alterations in catalytic activity and virus maturation produced by mutation of the conserved histidine residues of herpes simplex virus type 1 protease.Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a.Herpesvirus protease inhibition by dimer disruption.Displacements of prohead protease genes in the late operons of double-stranded-DNA bacteriophagesDouble-stranded DNA bacteriophage prohead protease is homologous to herpesvirus proteaseStructure of the foot-and-mouth disease virus leader protease: a papain-like fold adapted for self-processing and eIF4G recognition.Inhibition of human cytomegalovirus proteinase by salcomine derivatives.Potent beta-lactam inhibitors of human cytomegalovirus protease.
P2860
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P2860
A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease
description
1996 nî lūn-bûn
@nan
1996 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
A new serine-protease fold rev ...... human cytomegalovirus protease
@ast
A new serine-protease fold rev ...... human cytomegalovirus protease
@en
A new serine-protease fold rev ...... human cytomegalovirus protease
@nl
type
label
A new serine-protease fold rev ...... human cytomegalovirus protease
@ast
A new serine-protease fold rev ...... human cytomegalovirus protease
@en
A new serine-protease fold rev ...... human cytomegalovirus protease
@nl
prefLabel
A new serine-protease fold rev ...... human cytomegalovirus protease
@ast
A new serine-protease fold rev ...... human cytomegalovirus protease
@en
A new serine-protease fold rev ...... human cytomegalovirus protease
@nl
P2093
P3181
P356
P1433
P1476
A new serine-protease fold rev ...... human cytomegalovirus protease
@en
P2093
P2888
P3181
P356
10.1038/383272A0
P407
P577
1996-09-19T00:00:00Z
P5875
P6179
1000855945