Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.
about
Current and potential treatments for ubiquitous but neglected herpesvirus infectionsSubstrate Modulation of Enzyme Activity in the Herpesvirus Protease FamilyBroad-Spectrum Allosteric Inhibition of Herpesvirus ProteasesProtease specificity determination by using cellular libraries of peptide substrates (CLiPS).Using specificity to strategically target proteases.Positional scanning synthetic combinatorial libraries for substrate profiling.Inhibition of a viral enzyme by a small-molecule dimer disruptor.Allosteric regulation of protease activity by small molecules.Maturation mechanism of severe acute respiratory syndrome (SARS) coronavirus 3C-like proteinase.A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor.Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain.Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric ProteaseAnti-herpesvirus agents: a patent and literature review (2003 to present).Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a.Computational Studies of Benzoxazinone Derivatives as Antiviral Agents against Herpes Virus Type 1 Protease.Mutational analysis of the Pseudomonas aeruginosa myovirus KZ morphogenetic protease gp175.Cytomegalovirus capsid protease: biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (assemblin)Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
P2860
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P2860
Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Communication between the acti ...... a transition-state inhibitor.
@ast
Communication between the acti ...... a transition-state inhibitor.
@en
type
label
Communication between the acti ...... a transition-state inhibitor.
@ast
Communication between the acti ...... a transition-state inhibitor.
@en
prefLabel
Communication between the acti ...... a transition-state inhibitor.
@ast
Communication between the acti ...... a transition-state inhibitor.
@en
P2093
P2860
P356
P1476
Communication between the acti ...... a transition-state inhibitor.
@en
P2093
Alan B Marnett
Anson M Nomura
Charles S Craik
Nobuhisa Shimba
Paul R Ortiz de Montellano
P2860
P304
P356
10.1073/PNAS.0401613101
P407
P577
2004-04-26T00:00:00Z