about
Current and potential treatments for ubiquitous but neglected herpesvirus infectionsActive residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virusComplex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal formCrystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesisThe structure of aspartyl dipeptidase reveals a unique fold with a Ser-His-Glu catalytic triadStructural investigations of the active-site mutant Asn156Ala of outer membrane phospholipase A: Function of the Asn-His interaction in the catalytic triadSubstrate Modulation of Enzyme Activity in the Herpesvirus Protease FamilyCrystal structure of varicella-zoster virus proteaseConserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus proteaseUnconventional serine proteases: variations on the catalytic Ser/His/Asp triad configurationDimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine ProteaseExtensive subunit contacts underpin herpesvirus capsid stability and interior-to-exterior allostery.Overview of protein structural and functional folds.The herpesvirus proteases as targets for antiviral chemotherapy.Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.Inhibition of a viral enzyme by a small-molecule dimer disruptor.Structural and energetic determinants of the S1-site specificity in serine proteases.Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity.Recent strategies in the development of new human cytomegalovirus inhibitors.Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions.Non-nucleoside inhibitors of herpesviruses.Enzymatic activities of human cytomegalovirus maturational protease assemblin and its precursor (pPR, pUL80a) are comparable: [corrected] maximal activity of pPR requires self-interaction through its scaffolding domain.The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).Identification of the sites of interaction between the scaffold and outer shell in herpes simplex virus-1 capsids by difference electron imaging.Procapsid assembly, maturation, nuclear exit: dynamic steps in the production of infectious herpesvirions.Anti-herpesvirus agents: a patent and literature review (2003 to present).Viruses and viral proteins.Influenza virus RNA polymerase PA subunit is a novel serine protease with Ser624 at the active site.Active site mutants of human herpesvirus-6 proteinase.Protease inhibitors as antiviral agents.Cytomegalovirus protease targeted prodrug development.Expression and characterization of recombinant murine cytomegalovirus protease.Alterations in catalytic activity and virus maturation produced by mutation of the conserved histidine residues of herpes simplex virus type 1 protease.Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a.Herpesvirus protease inhibition by dimer disruption.Displacements of prohead protease genes in the late operons of double-stranded-DNA bacteriophagesInhibition of human cytomegalovirus proteinase by salcomine derivatives.Potent beta-lactam inhibitors of human cytomegalovirus protease.Cytomegalovirus capsid protease: biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (assemblin)Novel yeast cell-based assay to screen for inhibitors of human cytomegalovirus protease in a high-throughput format.
P2860
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P2860
description
1996 nî lūn-bûn
@nan
1996 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Unique fold and active site in cytomegalovirus protease
@ast
Unique fold and active site in cytomegalovirus protease
@en
Unique fold and active site in cytomegalovirus protease
@nl
type
label
Unique fold and active site in cytomegalovirus protease
@ast
Unique fold and active site in cytomegalovirus protease
@en
Unique fold and active site in cytomegalovirus protease
@nl
prefLabel
Unique fold and active site in cytomegalovirus protease
@ast
Unique fold and active site in cytomegalovirus protease
@en
Unique fold and active site in cytomegalovirus protease
@nl
P2093
P3181
P356
P1433
P1476
Unique fold and active site in cytomegalovirus protease
@en
P2093
A G DiLella
C A Janson
S S Abdel-Meguid
P2888
P3181
P356
10.1038/383275A0
P407
P577
1996-09-19T00:00:00Z
P6179
1053398966