Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position

Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position

Item
http://www.wikidata.org/entity/Q27765106
Rational design of potent, small, synthetic allosteric inhibitors of thrombinFragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexesAdvances in the development of thrombin inhibitorsA network-based multi-target computational estimation scheme for anticoagulant activities of compoundsSmall, noncovalent serine protease inhibitors.Contribution of explicit solvent effects to the binding affinity of small-molecule inhibitors in blood coagulation factor serine proteases.Synthesis and biochemical evaluation of triazole/tetrazole-containing sulfonamides against thrombin and related serine proteases.Quantum and molecular dynamics study for binding of macrocyclic inhibitors to human alpha-thrombin.Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.Free Fatty Acids Modulate Thrombin Mediated Fibrin Generation Resulting in Less Stable Clots.(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.Oral, direct thrombin and factor Xa inhibitors: the replacement for warfarin, leeches, and pig intestines?The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors.Cl-pi interactions in protein-ligand complexes.4-Fluoroprolines: Conformational Analysis and Effects on the Stability and Folding of Peptides and Proteins.Site-Specific Fragment Identification Guided by Single-Step Free Energy Perturbation CalculationsA fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.
P2860

Design and synthesis of a series of potent and orally bioavailable noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position

Item
http://www.wikidata.org/entity/Q27765106
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
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1998年論文
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1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
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name
Design and synthesis of a seri ...... asic groups in the P1 position
@ast
Design and synthesis of a seri ...... asic groups in the P1 position
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Design and synthesis of a seri ...... asic groups in the P1 position
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type
label
Design and synthesis of a seri ...... asic groups in the P1 position
@ast
Design and synthesis of a seri ...... asic groups in the P1 position
@en
Design and synthesis of a seri ...... asic groups in the P1 position
@nl
prefLabel
Design and synthesis of a seri ...... asic groups in the P1 position
@ast
Design and synthesis of a seri ...... asic groups in the P1 position
@en
Design and synthesis of a seri ...... asic groups in the P1 position
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P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Design and synthesis of a seri ...... asic groups in the P1 position
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P2093
P304
P31
P356
P407
P433
P478
P577
P698