(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.
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Adenosine receptors as therapeutic targetsTranslocation of arrestin induced by human A(3) adenosine receptor ligands in an engineered cell line: comparison with G protein-dependent pathwaysRecent developments in adenosine receptor ligands and their potential as novel drugsEmerging adenosine receptor agonistsAnticonvulsant activity of B2, an adenosine analog, on chemical convulsant-induced seizuresThe imaging probe development center and the production of molecular imaging probesThe A3 adenosine receptor attenuates the calcium rise triggered by NMDA receptors in retinal ganglion cellsSynthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional rolesStimulation of the P2X7 receptor kills rat retinal ganglion cells in vivo.Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moietySpinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy.A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion.Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition ElementA3 adenosine receptor agonist reduces brain ischemic injury and inhibits inflammatory cell migration in rats.Click modification in the N6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition.Controlling murine and rat chronic pain through A3 adenosine receptor activationStructure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.Purine receptors: GPCR structure and agonist designLighting up G protein-coupled purinergic receptors with engineered fluorescent ligands."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonistsTruncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane SubstitutionsAction of nucleosides and nucleotides at 7 transmembrane-spanning receptors.Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.Synthesis of enantiomerically pure (S)-methanocarbaribo uracil nucleoside derivatives for use as antiviral agents and P2Y receptor ligands.The A3 adenosine receptor agonist CF502 inhibits the PI3K, PKB/Akt and NF-kappaB signaling pathway in synoviocytes from rheumatoid arthritis patients and in adjuvant-induced arthritis ratsSynthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography.Synthesis and pharmacological characterization of [(125)I]MRS1898, a high-affinity, selective radioligand for the rat A(3) adenosine receptor.Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species.Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches.Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms.A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors.
P2860
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P2860
(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
(N)-methanocarba 2,N6-disubsti ...... 3 adenosine receptor agonists.
@ast
(N)-methanocarba 2,N6-disubsti ...... 3 adenosine receptor agonists.
@en
type
label
(N)-methanocarba 2,N6-disubsti ...... 3 adenosine receptor agonists.
@ast
(N)-methanocarba 2,N6-disubsti ...... 3 adenosine receptor agonists.
@en
prefLabel
(N)-methanocarba 2,N6-disubsti ...... 3 adenosine receptor agonists.
@ast
(N)-methanocarba 2,N6-disubsti ...... 3 adenosine receptor agonists.
@en
P2093
P2860
P356
P1476
(N)-methanocarba 2,N6-disubsti ...... A3 adenosine receptor agonists
@en
P2093
Bhalchandra V Joshi
Heng T Duong
Soo-Kyung Kim
Susanna Tchilibon
P2860
P304
P356
10.1021/JM049580R
P407
P577
2005-03-01T00:00:00Z