A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.

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http://www.wikidata.org/entity/Q44857393
The lab oddity prevails: discovery of pan-CDK inhibitor (R)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the treatment of cancerUnderstanding organofluorine chemistry. An introduction to the C-F bondFluorous mixture synthesis of two libraries with hydantoin-, and benzodiazepinedione-fused heterocyclic scaffolds.Fluorous-enhanced multicomponent reactions for making drug-like library scaffolds.Microwave-Enhanced High-Speed Fluorous Synthesis.Fluorous Synthesis of Hydantoin-, Piperazinedione-, and Benzodiazepinedione-Fused Tricyclic and Tetracyclic Ring Systems.Fluorous parallel synthesis of a piperazinedione-fused tricyclic compound libraryAromatic rings in chemical and biological recognition: energetics and structures.Introduction of fluorine and fluorine-containing functional groups.Fluorine in drug design: a case study with fluoroanisoles.Fluorination methods for drug discovery and development.Progress towards water-soluble triazole-based selective MMP-2 inhibitors.Aromatic N versus aromatic F: bioisosterism discovered in RNA base pairing interactions leads to a novel class of universal base analogs.Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation.Nucleophilic trifluoromethylation of cyclic imides using (trifluoromethyl)trimethylsilane CF3SiMe3.Bisubstrate Inhibitors of the Enzyme Catechol O-Methyltransferase (COMT): Efficient Inhibition Despite the Lack of a Nitro Group
P2860

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions.

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http://www.wikidata.org/entity/Q44857393
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2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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name
A fluorine scan of the phenyla ...... lecular C-F...CN interactions.
@en
A fluorine scan of the phenyla ...... lecular C-F...CN interactions.
@nl
type
label
A fluorine scan of the phenyla ...... lecular C-F...CN interactions.
@en
A fluorine scan of the phenyla ...... lecular C-F...CN interactions.
@nl
prefLabel
A fluorine scan of the phenyla ...... lecular C-F...CN interactions.
@en
A fluorine scan of the phenyla ...... lecular C-F...CN interactions.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698
P356
P1433
P1476
A fluorine scan of the phenyla ...... lecular C-F...CN interactions.
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P698