Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands
about
The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analoguesNucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallographyThe effect of substrate binding on the conformation and structural stability of Herpes simplex virus type 1 thymidine kinaseEnzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanismCrystal structure of varicella zoster virus thymidine kinaseStructural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinaseSynthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivoStructure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovirFunctional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutantsBiochemical and structural characterization of (South)-methanocarbathymidine that specifically inhibits growth of herpes simplex virus type 1 thymidine kinase-transduced osteosarcoma cellsiPfam: a database of protein family and domain interactions found in the Protein Data BankTSCC: Two-Stage Combinatorial Clustering for virtual screening using protein-ligand interactions and physicochemical features.iGEMDOCK: a graphical environment of enhancing GEMDOCK using pharmacological interactions and post-screening analysis.SiMMap: a web server for inferring site-moiety map to recognize interaction preferences between protein pockets and compound moieties.The enantioselectivity of enzymes involved in current antiviral therapy using nucleoside analogues: a new strategy?Synthesis and in vitro evaluation of 5-[(18)f]fluoroalkyl pyrimidine nucleosides for molecular imaging of herpes simplex virus type 1 thymidine kinase reporter gene expression.Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivoA Bioorthogonal Chemical Reporter of Viral Infection.Systematic placement of structural water molecules for improved scoring of protein-ligand interactionsThermodynamics of protein-ligand interactions: history, presence, and future aspects.A new nucleoside analogue with potent activity against mutant sr39 herpes simplex virus-1 (HSV-1) thymidine kinase (TK).Development of a cancer-marker activated enzymatic switch from the herpes simplex virus thymidine kinase.The role of herpes simplex virus-1 thymidine kinase alanine 168 in substrate specificity.Famciclovir: a focus on efficacy and safety.Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging.Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudinDocking and antiherpetic activity of 2-aminobenzo[de]-isoquinoline-1,3-diones.Testing the sensitivities of noncognate inhibitors to varicella zoster virus thymidine kinase: implications for postherpetic neuralgia therapy with existing agents.2,3-Dihydroxy-quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase.The rational of catalytic activity of herpes simplex virus thymidine kinase. a combined biochemical and quantum chemical study.Classical molecular interaction potentials: improved setup procedure in molecular dynamics simulations of proteins.Methodology and problems of protein-ligand docking: case study of dihydroorotate dehydrogenase, thymidine kinase, and phosphodiesterase 4.Molecular modeling of the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.Modulated nucleoside kinases as tools to improve the activation of therapeutic nucleoside analogues.Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation.Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase. A calorimetric study.Directed evolution of thymidine kinase for AZT phosphorylation using DNA family shuffling.Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster.Strategies in the Design of Antiviral DrugsSynthesis, Antiviral Evaluation, and Computational Studies of Cyclobutane and CyclobuteneL-Nucleoside Analogues
P2860
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P2860
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Exploring the active site of h ...... th aciclovir and other ligands
@ast
Exploring the active site of h ...... th aciclovir and other ligands
@en
Exploring the active site of h ...... th aciclovir and other ligands
@nl
type
label
Exploring the active site of h ...... th aciclovir and other ligands
@ast
Exploring the active site of h ...... th aciclovir and other ligands
@en
Exploring the active site of h ...... th aciclovir and other ligands
@nl
prefLabel
Exploring the active site of h ...... th aciclovir and other ligands
@ast
Exploring the active site of h ...... th aciclovir and other ligands
@en
Exploring the active site of h ...... th aciclovir and other ligands
@nl
P2093
P2860
P50
P1433
P1476
Exploring the active site of h ...... th aciclovir and other ligands
@en
P2093
E de Clerq
J N Champness
M R Sanderson
M S Bennett
R L Jarvest
W C Summers
P2860
P304
P356
10.1002/(SICI)1097-0134(19980815)32:3<350::AID-PROT10>3.0.CO;2-8
P407
P577
1998-08-01T00:00:00Z