Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue
about
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimeticsStructure of mammalian protein geranylgeranyltransferase type-IClathrin self-assembly is mediated by a tandemly repeated superhelixReaction path of protein farnesyltransferase at atomic resolutionSynthesis, Properties, and Applications of Diazotrifluropropanoyl-Containing Photoactive Analogs of Farnesyl Diphosphate Containing Modified Linkages for Enhanced StabilityCrystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug designCatalysis of methyl group transfers involving tetrahydrofolate and B(12)Lysine(164)alpha of protein farnesyltransferase is important for both CaaX substrate binding and catalysisPotent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation.Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases.The CaaX specificities of Arabidopsis protein prenyltransferases explain era1 and ggb phenotypesCloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma bruceiSynthesis and conformational analysis of bicyclic extended dipeptide surrogates.Structure, mechanism and function of prenyltransferases.Farnesyltransferase--new insights into the zinc-coordination sphere paradigm: evidence for a carboxylate-shift mechanism.Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation.Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferaseLipid posttranslational modifications. Farnesyl transferase inhibitors.Evaluation of alkyne-modified isoprenoids as chemical reporters of protein prenylation.Murine guanylate-binding protein: incomplete geranylgeranyl isoprenoid modification of an interferon-gamma-inducible guanosine triphosphate-binding proteinA defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex.Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.Protein prenylation: enzymes, therapeutics, and biotechnology applications.Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.Photochemical modulation of Ras-mediated signal transduction using caged farnesyltransferase inhibitors: activation by one- and two-photon excitationLipid-modified proteins as biomarkers for cardiovascular disease: a review.Inhibition of farnesyltransferase: a rational approach to treat cancer?A photoactive isoprenoid diphosphate analogue containing a stable phosphonate linkage: synthesis and biochemical studies with prenyltransferasesNovel route to chaetomellic acid A and analogues: serendipitous discovery of a more competent FTase inhibitor.Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasitesA versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes.Insights into the mechanistic dichotomy of the protein farnesyltransferase peptide substrates CVIM and CVLS.A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors.Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.Substituted imidazo[1,2-a]pyridines as β-strand peptidomimetics.Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity.Computational studies of the farnesyltransferase ternary complex part II: the conformational activation of farnesyldiphosphate.Successful molecular dynamics simulation of the zinc-bound farnesyltransferase using the cationic dummy atom approach.Farnesyl diphosphate analogues with omega-bioorthogonal azide and alkyne functional groups for protein farnesyl transferase-catalyzed ligation reactions.Finding a needle in the haystack: computational modeling of Mg2+ binding in the active site of protein farnesyltransferase.
P2860
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P2860
Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue
description
1998 nî lūn-bûn
@nan
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
name
Crystal structure of farnesyl ...... farnesyl diphosphate analogue
@ast
Crystal structure of farnesyl ...... farnesyl diphosphate analogue
@en
Crystal structure of farnesyl ...... farnesyl diphosphate analogue
@nl
type
label
Crystal structure of farnesyl ...... farnesyl diphosphate analogue
@ast
Crystal structure of farnesyl ...... farnesyl diphosphate analogue
@en
Crystal structure of farnesyl ...... farnesyl diphosphate analogue
@nl
prefLabel
Crystal structure of farnesyl ...... farnesyl diphosphate analogue
@ast
Crystal structure of farnesyl ...... farnesyl diphosphate analogue
@en
Crystal structure of farnesyl ...... farnesyl diphosphate analogue
@nl
P2093
P356
P1433
P1476
Crystal structure of farnesyl ...... farnesyl diphosphate analogue
@en
P2093
C L Strickland
J Schwartz
W T Windsor
P304
P356
10.1021/BI981197Z
P407
P577
1998-11-24T00:00:00Z