Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE - Wikidata - wikimedia - TriplyDB

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE

http://www.wikidata.org/entity/Q27861959

about

Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network Plasmodium falciparum susceptibility to antimalarial drugs: global data issued from the Pasteur Institutes international network The interplay between drug resistance and fitness in malaria parasites Application of genomics to field investigations of malaria by the international centers of excellence for malaria research Global analysis of Plasmodium falciparum Na(+)/H(+) exchanger (pfnhe-1) allele polymorphism and its usefulness as a marker of in vitro resistance to quinine A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum In vitro selection of Plasmodium falciparum drug-resistant parasite lines.In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.Identification of inhibitors for putative malaria drug targets among novel antimalarial compounds.Analysis of malaria parasite phenotypes using experimental genetic crosses of Plasmodium falciparum.Polymorphisms in Pfmdr1, Pfcrt, and Pfnhe1 genes are associated with reduced in vitro activities of quinine in Plasmodium falciparum isolates from western Kenya Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa Artemisone effective against murine cerebral malaria In vitro sensitivity of Plasmodium falciparum clinical isolates from the China-Myanmar border area to quinine and association with polymorphism in the Na+/H+ exchanger.Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda Polymorphism of Plasmodium falciparum Na(+)/H(+) exchanger is indicative of a low in vitro quinine susceptibility in isolates from Viet Nam.Differential association of Plasmodium falciparum Na+/H+ exchanger polymorphism and quinine responses in field- and culture-adapted isolates of Plasmodium falciparum.Polymorphisms of the pfmdr1 but not the pfnhe-1 gene is associated with in vitro quinine sensitivity in Thai isolates of Plasmodium falciparum Malaria drug resistance: new observations and developments.Quinine treatment selects the pfnhe-1 ms4760-1 polymorphism in Malian patients with Falciparum malaria In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger transporter (Pfnhe-1) gene in 393 isolates from Dakar, Senegal Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria Gancidin W, a potential low-toxicity antimalarial agent isolated from an endophytic Streptomyces SUK10 Antimalarial drugs: modes of action and mechanisms of parasite resistance.How can we identify parasite genes that underlie antimalarial drug resistance?Drug-resistant malaria: molecular mechanisms and implications for public health.Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Harnessing genomics and genome biology to understand malaria biology.Membrane transport in the malaria parasite and its host erythrocyte.Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria.Antimalarial Drug Resistance: A Threat to Malaria Elimination.Atorvastatin as a potential anti-malarial drug: in vitro synergy in combinational therapy with quinine against Plasmodium falciparum.In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum.Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum.Quinine localizes to a non-acidic compartment within the food vacuole of the malaria parasite Plasmodium falciparum.Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters.

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P2860

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE

http://www.wikidata.org/entity/Q27861959

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2009 nî lūn-bûn

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2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2009 թվականի հունիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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Probing the multifactorial bas ...... sodium-proton exchanger PfNHE

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Probing the multifactorial bas ...... sodium-proton exchanger PfNHE

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Probing the multifactorial bas ...... sodium-proton exchanger PfNHE

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Probing the multifactorial bas ...... sodium-proton exchanger PfNHE

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Probing the multifactorial bas ...... sodium-proton exchanger PfNHE

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Probing the multifactorial bas ...... sodium-proton exchanger PfNHE

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Probing the multifactorial bas ...... sodium-proton exchanger PfNHE

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Probing the multifactorial bas ...... sodium-proton exchanger PfNHE

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J.MOLBIOPARA.2009.01.011

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Molecular and Biochemical Parasitology

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Probing the multifactorial bas ...... sodium-proton exchanger PfNHE

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David J Johnson

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Jigar Patel

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Karen Hayton

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Louis J Nkrumah

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Michael T Ferdig

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Paul M Riegelhaupt

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Pedro Moura

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Thomas E Wellems

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P2860

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

Identification and localization of ERD2 in the malaria parasite Plasmodium falciparum: separation from sites of sphingomyelin synthesis and implications for organization of the Golgi

A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum

Transport of lactate and pyruvate in the intraerythrocytic malaria parasite, Plasmodium falciparum

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number

Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms.

Antimalarial multi-drug resistance in Asia: mechanisms and assessment.

Transporters involved in resistance to antimalarial drugs.

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.

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122-31

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scholarly article

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10.1016/J.MOLBIOPARA.2009.01.011

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2

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165

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David A. Fidock

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24414327

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19428659

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Plasmodium falciparum

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