PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans. - Wikidata - wikimedia - TriplyDB

PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

http://www.wikidata.org/entity/Q33727405

about

Structure-guided design of selective Epac1 and Epac2 agonists Cyclic AMP dynamics in the pancreatic β-cell Glucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytes Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion Isoform-specific antagonists of exchange proteins directly activated by cAMP Cyclic AMP sensor EPAC proteins and energy homeostasis.Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.The future of EPAC-targeted therapies: agonism versus antagonism Activators of PKA and Epac distinctly influence insulin secretion and cytosolic Ca2+ in female mouse islets stimulated by glucose and tolbutamide.Snapin mediates incretin action and augments glucose-dependent insulin secretion Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells.Enhanced Peptide Stability Against Protease Digestion Induced by Intrinsic Factor Binding of a Vitamin B12 Conjugate of Exendin-4.Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.Role of phospholipase Cε in physiological phosphoinositide signaling networks.Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx.Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo Modeling analysis of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ mobilization under the control of glucagon-like peptide-1 in mouse pancreatic β-cells.Pancreatic β-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A The minimal promoter region of the dense-core vesicle protein IA-2: transcriptional regulation by CREB.IG20/MADD plays a critical role in glucose-induced insulin secretion.Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells.New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.Multilevel control of glucose homeostasis by adenylyl cyclase 8.cAMP signalling in insulin and glucagon secretion.Synthesis, characterization and pharmacodynamics of vitamin-B(12)-conjugated glucagon-like peptide-1.PKA-independent cAMP stimulation of white adipocyte exocytosis and adipokine secretion: modulations by Ca2+ and ATP.Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Chimeric peptide EP45 as a dual agonist at GLP-1 and NPY2R receptors.Sulphonylurea receptor-1, sulphonylureas and amplification of insulin secretion by Epac activation in β cells.Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac.

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P2860

PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.

http://www.wikidata.org/entity/Q33727405

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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AJPENDO.00630.2009

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American Journal of Physiology - Endocrinology and Metabolism

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PKA-dependent potentiation of ...... in human islets of Langerhans.

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Colin A Leech

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Elvira Dzhura

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Frank Schwede

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George G Holz

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Grant G Kelley

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Hans-G Genieser

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Igor Dzhura

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Michael W Roe

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Oleg G Chepurny

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Xiangquan Li

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P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

A new generation of Ca2+ indicators with greatly improved fluorescence properties

Triggering and amplifying pathways of regulation of insulin secretion by glucose.

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

Insulin secretion: a high-affinity Ca2+ sensor after all?

cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.

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10.1152/AJPENDO.00630.2009

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