A cluster of pathogenic mutations in the 3'-5' exonuclease domain of DNA polymerase gamma defines a novel module coupling DNA synthesis and degradation.
about
Antimutator alleles of yeast DNA polymerase gamma modulate the balance between DNA synthesis and excisionMitochondrial DNA replication and disease: insights from DNA polymerase γ mutationsDNA polymerase γ and disease: what we have learned from yeastAlpers-Huttenlocher syndromeGenetic instability in budding and fission yeast-sources and mechanismsMMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variantsPathogenicity in POLG syndromes: DNA polymerase gamma pathogenicity prediction server and database.Mitochondrial genome maintenance in health and disease.C-terminal extension of the yeast mitochondrial DNA polymerase determines the balance between synthesis and degradation.Overexpression of DNA polymerase zeta reduces the mitochondrial mutability caused by pathological mutations in DNA polymerase gamma in yeast.Defects in mitochondrial DNA replication and human diseasePolymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.Alpers disease mutations in human DNA polymerase gamma cause catalytic defects in mitochondrial DNA replication by distinct mechanismsEvolution of the metazoan mitochondrial replicase.Clustering of Alpers disease mutations and catalytic defects in biochemical variants reveal new features of molecular mechanism of the human mitochondrial replicase, Pol γ.Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies.Yeast model analysis of novel polymerase gamma variants found in patients with autosomal recessive mitochondrial disease.Mapping 136 pathogenic mutations into functional modules in human DNA polymerase γ establishes predictive genotype-phenotype correlations for the complete spectrum of POLG syndromes.The exonuclease activity of the yeast mitochondrial DNA polymerase γ suppresses mitochondrial DNA deletions between short direct repeats in Saccharomyces cerevisiaeClinical and molecular features of POLG-related mitochondrial disease.The power of yeast to model diseases of the powerhouse of the cell.Yeast cells expressing the human mitochondrial DNA polymerase reveal correlations between polymerase fidelity and human disease progressionMitochondrial DNA maintenance: an appraisal.The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication.Synergistic Effects of the in cis T251I and P587L Mitochondrial DNA Polymerase γ Disease Mutations.
P2860
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P2860
A cluster of pathogenic mutations in the 3'-5' exonuclease domain of DNA polymerase gamma defines a novel module coupling DNA synthesis and degradation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
A cluster of pathogenic mutati ...... DNA synthesis and degradation.
@ast
A cluster of pathogenic mutati ...... DNA synthesis and degradation.
@en
A cluster of pathogenic mutati ...... DNA synthesis and degradation.
@nl
type
label
A cluster of pathogenic mutati ...... DNA synthesis and degradation.
@ast
A cluster of pathogenic mutati ...... DNA synthesis and degradation.
@en
A cluster of pathogenic mutati ...... DNA synthesis and degradation.
@nl
prefLabel
A cluster of pathogenic mutati ...... DNA synthesis and degradation.
@ast
A cluster of pathogenic mutati ...... DNA synthesis and degradation.
@en
A cluster of pathogenic mutati ...... DNA synthesis and degradation.
@nl
P356
P1476
A cluster of pathogenic mutati ...... DNA synthesis and degradation.
@en
P2093
Françoise Foury
Karolina Szczepanowska
P304
P356
10.1093/HMG/DDQ267
P407
P577
2010-09-15T00:00:00Z