about
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stabilityAlternative induction of meiotic recombination from single-base lesions of DNA deaminasesMus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?The fission yeast FANCM ortholog directs non-crossover recombination during meiosisEfficient second strand cleavage during Holliday junction resolution by RuvC requires both increased junction flexibility and an exposed 5' phosphate.Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination.Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombinationSlx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein.Crossover promotion and prevention.Exploring the roles of Mus81-Eme1/Mms4 at perturbed replication forks.The FANCM family of DNA helicases/translocases.Emerging roles for centromere-associated proteins in DNA repair and genetic recombination.Sequence specificity and biochemical characterization of the RusA Holliday junction resolvase of Escherichia coli.Interactions between RuvA and RuvC at Holliday junctions: inhibition of junction cleavage and formation of a RuvA-RuvC-DNA complex.The RecQ DNA helicase Rqh1 constrains Exonuclease 1-dependent recombination at stalled replication forks.The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant.Recombination occurs within minutes of replication blockage by RTS1 producing restarted forks that are prone to collapseCorrection of proliferation and drug sensitivity defects in the progeroid Werner's Syndrome by Holliday junction resolution.DNA repair by a Rad22-Mus81-dependent pathway that is independent of Rhp51.The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability.Fbh1 limits Rad51-dependent recombination at blocked replication forks.The F-Box DNA helicase Fbh1 prevents Rhp51-dependent recombination without mediator proteins.Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication.How not to get cross(ed): a novel role for FANCM orthologs in meiotic recombination.The role of the SAP motif in promoting Holliday junction binding and resolution by SpCCE1.A failure of meiotic chromosome segregation in a fbh1Delta mutant correlates with persistent Rad51-DNA associations.Replication fork blockage by RTS1 at an ectopic site promotes recombination in fission yeast.MHF1-2/CENP-S-X performs distinct roles in centromere metabolism and genetic recombination.The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair.Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.Targeting Holliday junctions by the RecG branch migration protein of Escherichia coli.Cleavage of model replication forks by fission yeast Mus81-Eme1 and budding yeast Mus81-Mms4.Reverse branch migration of Holliday junctions by RecG protein: a new mechanism for resolution of intermediates in recombination and DNA repair.Factors affecting template switch recombination associated with restarted DNA replicationThe PCNA unloader Elg1 promotes recombination at collapsed replication forks in fission yeast.Altered SOS induction associated with mutations in recF, recO and recRA new Holliday junction resolving enzyme from Schizosaccharomyces pombe that is homologous to CCE1 from Saccharomyces cerevisiaeThe Holliday junction resolvase SpCCE1 prevents mitochondrial DNA aggregation in Schizosaccharomyces pombeSubstrate specificity of the SpCCE1 holliday junction resolvase of Schizosaccharomyces pombe
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description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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name
Matthew C Whitby
@ast
Matthew C Whitby
@en
Matthew C Whitby
@es
Matthew C Whitby
@nl
Matthew C Whitby
@sl
type
label
Matthew C Whitby
@ast
Matthew C Whitby
@en
Matthew C Whitby
@es
Matthew C Whitby
@nl
Matthew C Whitby
@sl
prefLabel
Matthew C Whitby
@ast
Matthew C Whitby
@en
Matthew C Whitby
@es
Matthew C Whitby
@nl
Matthew C Whitby
@sl
P106
P21
P31
P496
0000-0003-0951-3374