Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures - Wikidata - wikimedia - TriplyDB

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures

http://www.wikidata.org/entity/Q36499106

about

CtIP is required to initiate replication-dependent interstrand crosslink repair Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair Efficient second strand cleavage during Holliday junction resolution by RuvC requires both increased junction flexibility and an exposed 5' phosphate.MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution.Cruciform structures are a common DNA feature important for regulating biological processes.Mechanism of Holliday junction resolution by the human GEN1 protein Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes.Holliday junction affinity of the base excision repair factor Endo III contributes to cholera toxin phage integration.The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination.Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair.The DNA replication factor RFC1 is required for interference-sensitive meiotic crossovers in Arabidopsis thaliana.Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates.Effect of EME1 exon variant Ile350Thr on risk and early onset of breast cancer in southern Chinese women.Quality control of homologous recombination.Holliday junction resolvases.Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.Substrate specificity of the MUS81-EME2 structure selective endonuclease.Digital gene expression profiling analysis of DNA repair pathways in colon cancer stem population of HT29 cells.Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing.Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage.Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4.Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replication.Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae.Cooperative control of holliday junction resolution and DNA repair by the SLX1 and MUS81-EME1 nucleases.Aberrant chromosome morphology in human cells defective for Holliday junction resolution.RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana.Two distinct MUS81-EME1 complexes from Arabidopsis process Holliday junctions.Resolvase OsGEN1 Mediates DNA Repair by Homologous Recombination.

P2860

Q24303573-A023E9B6-CD20-40CC-ADD5-1EFA21A940C1 Q24314301-9CBC4A18-9114-4B0C-B2E0-B4B83A991FBE Q24314357-CEC51C67-A7B6-4A9A-8226-7E92607447A3 Q24337537-BCBC239A-04E4-4735-B42A-980BF0A63C46 Q27679816-F85AFBB3-C75C-4202-B5F7-40C8D2551A60 Q27939265-5C21A543-5172-43AD-B083-609D652E34E8 Q27939352-4B3C2FDF-27F5-47FF-B7C6-32B246386989 Q28474239-6818DAF1-14D0-4B7D-AEF0-761C1C9E906E Q28474884-F9760533-B14F-49F7-A498-B032401EE389 Q30862224-24860DAB-CE7E-4641-A112-41F134D65773 Q33369076-DFE4D810-BD33-4554-8C05-AA8A8C2F7FE9 Q33635502-50F0A1C0-44A4-456C-9C70-AFC35B8F1DCD Q33737790-8A72ACB7-96C7-431B-A2DB-3148C5FCAF73 Q33982201-35E1611A-2520-493C-86B0-EE68C24D639B Q33998890-3BCA7EC1-D3A9-4870-974B-B102BD2FCBF3 Q34025948-FF0A711B-72A1-41C7-AF52-A1E998E9D560 Q34366418-9E21409B-72D8-4A7C-9384-1E98A6A7C174 Q34399650-6C616AAF-95EB-4B79-AC80-1602311FB8BC Q35034362-0FAE3241-68B9-4BBA-BB10-29E4A0C79C64 Q35209502-A7A26225-493E-43BB-91C7-413102CC4D73 Q35943337-DFD0CD88-6645-4F4C-8029-19CDD5A079EE Q36210916-E82E0DAE-9BBD-4C97-B11F-6E3352AAF215 Q36384393-0C828F78-3CEF-4962-A50C-6DC7C37E2B62 Q36695597-05456CFA-567B-4F0A-8E70-CEDCCE05F15B Q36878102-1C7290D6-7F4C-4653-AF56-111BA673A68C Q38214443-336FBBE2-DA50-4AC6-8B27-7A052D4BC019 Q38245723-9219E62D-9944-44ED-91AF-84597BD86E1B Q38256335-17631772-AD0C-4055-936F-6135C8BFF8E4 Q38593922-83FD9977-FB1A-47DF-B743-B50EB2119CF3 Q38727052-FD79B10E-948C-4208-8F1C-9EC88A3A5117 Q40101630-F51C64E6-5FF5-4E09-9756-A9FE61412E0D Q41785600-413C23F2-CC53-41F3-81B0-643A36B79AA2 Q42030288-EE69804A-33A2-4227-AB8C-C05ED4C0026E Q42160533-401C28FA-102E-44E9-AFCA-65B825FB553B Q42793326-9136EF6A-896A-4F55-802F-EC42EE2F080F Q42933602-DAA1F928-F51E-41CC-AD2E-92BBA2AAF5F2 Q43100849-ACB4A93C-6191-4E1D-B13A-7BD359CE161B Q45412951-1FF434C9-9ABE-4B73-AA85-7E564F249B72 Q48070483-0FAD4784-C540-4166-B5A3-89DB86CECCD9 Q48098663-A1D1A28B-8B71-4295-86E0-EA9E7F1AF9C8

P2860

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures

http://www.wikidata.org/entity/Q36499106

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年学术文章

@wuu

2008年学术文章

@zh-cn

2008年学术文章

@zh-hans

2008年学术文章

@zh-my

2008年学术文章

@zh-sg

2008年學術文章

@yue

2008年學術文章

@zh

2008年學術文章

@zh-hant

name

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures

@ast

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures

@en

type

label

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures

@ast

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures

@en

prefLabel

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures

@ast

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures

@en

P1433

Q36499106-B5EFCDA3-0BF7-488B-BE3A-E305F7F43680

P1476

Q36499106-DFEFD4B4-BFA6-43EE-A68C-5EF79BBC01D9

P2093

Q36499106-02585BB8-8ABD-4D8F-9C69-8330860F3C23

Q36499106-5227BD53-9782-4658-99C9-0D9938814EA5

P2860

Q36499106-10B30510-CCE2-4E3E-8050-C17DA1DEDE83

Q36499106-17277337-C80A-4B2A-AFFB-F005B50718F4

Q36499106-1FCB68F4-086B-4888-AFAC-6F97043D5A34

Q36499106-20C4897E-7757-4D5F-A562-09F0AF81AA85

Q36499106-2B959AA5-10BC-4375-B6FD-DE80105CDEBD

Q36499106-2C744955-7DA4-4596-A432-59FBA41CD98B

Q36499106-2EAFA1E9-3F53-4E3D-BB15-68780758E12E

Q36499106-30822110-3731-4AD4-B106-67FE86B4C12E

Q36499106-352BCA2F-E116-422D-8BD2-3C211024F3AF

Q36499106-375EA49D-999E-4322-9D9F-E8B8F59A4CE9

P304

Q36499106-E6CF4BF1-4265-41E4-B5EC-1385429B7AFE

P31

Q36499106-845CA7B7-7A7C-4734-B8C0-A8FB55AB20D8

P356

Q36499106-6B7863CE-F3E2-4B93-B735-90A9960E7F10

P407

Q36499106-3BE2CA6B-05F3-47AA-BD03-BE9141E03E29

P433

Q36499106-44605731-D4A7-407D-BD16-20D087C6AD54

P478

Q36499106-67D7C48A-C0E3-44B7-987D-C41C1C06D2B1

P577

Q36499106-330AD786-836F-48D7-85E4-EAE7F6FE2E08

P5875

Q36499106-C6A102F6-A986-4B48-9FDC-714A88552BBA

P698

Q36499106-C80F9CDD-E2A2-4392-BC91-8C10AE79B464

P932

Q36499106-AAC4A5E6-5DCA-4639-93BF-BE062115AEE4

P356

PNAS.0710291105

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures

@en

P2093

Clare H McGowan

http://www.w3.org/2001/XMLSchema#string

Ewan R Taylor

http://www.w3.org/2001/XMLSchema#string

P2860

Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities

Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells

Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae

Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1

Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells

RNA interference inhibition of Mus81 reduces mitotic recombination in human cells

Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells

FokI dimerization is required for DNA cleavage

X-ray and biochemical anatomy of an archaeal XPF/Rad1/Mus81 family nuclease: similarity between its endonuclease domain and restriction enzymes

Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease

P304

3757-3762

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0710291105

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

105

http://www.w3.org/2001/XMLSchema#string

P577

2008-02-29T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5542723

http://www.w3.org/2001/XMLSchema#string

P698

18310322

http://www.w3.org/2001/XMLSchema#string

P932

2268786

http://www.w3.org/2001/XMLSchema#string