A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.
about
The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phaseHexameric ring structure of human MCM10 DNA replication factorIdentification and characterization of a novel component of the human minichromosome maintenance complexInvolvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatinDomain architecture and biochemical characterization of vertebrate Mcm10Structural basis for DNA binding by replication initiator Mcm10Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replicationDrosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensationPhysical Interactions between Mcm10, DNA, and DNA PolymeraseSolution NMR Structure of the C-terminal DNA Binding Domain of Mcm10 Reveals a Conserved MCM MotifMcm10 Self-Association Is Mediated by an N-Terminal Coiled-Coil DomainMcm10 is required for the maintenance of transcriptional silencing in Saccharomyces cerevisiae.Mcm10 mediates the interaction between DNA replication and silencing machineriesMcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation.Two mcm3 mutations affect different steps in the initiation of DNA replication.Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae.A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast.Novel DNA binding properties of the Mcm10 protein from Saccharomyces cerevisiae.Interaction between PCNA and diubiquitinated Mcm10 is essential for cell growth in budding yeastDual roles for Mcm10 in DNA replication initiation and silencing at the mating-type loci.Mechanisms Governing DDK Regulation of the Initiation of DNA ReplicationAn Mcm10 Mutant Defective in ssDNA Binding Shows Defects in DNA Replication InitiationCell cycle-dependent proteolysis and phosphorylation of human Mcm10Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.Ultraviolet radiation stress triggers the down-regulation of essential replication factor Mcm10.Mcm10 proteolysis initiates before the onset of M-phase.An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7DNA replication forks pause at silent origins near the HML locus in budding yeastThe N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage.Characterization of Leishmania donovani MCM4: expression patterns and interaction with PCNA.CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplicationMultiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant allelesUbc4 and Not4 regulate steady-state levels of DNA polymerase-α to promote efficient and accurate DNA replication.Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG componentsOrigins and complexes: the initiation of DNA replication.A novel zinc finger is required for Mcm10 homocomplex assembly.Localization of human Mcm10 is spatially and temporally regulated during the S phase.Control of DNA replication licensing in a cell cycle.Replication fork stalling by bulky DNA damage: localization at active origins and checkpoint modulation
P2860
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P2860
A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A lesion in the DNA replicatio ...... s in Saccharomyces cerevisiae.
@ast
A lesion in the DNA replicatio ...... s in Saccharomyces cerevisiae.
@en
A lesion in the DNA replicatio ...... s in Saccharomyces cerevisiae.
@nl
type
label
A lesion in the DNA replicatio ...... s in Saccharomyces cerevisiae.
@ast
A lesion in the DNA replicatio ...... s in Saccharomyces cerevisiae.
@en
A lesion in the DNA replicatio ...... s in Saccharomyces cerevisiae.
@nl
prefLabel
A lesion in the DNA replicatio ...... s in Saccharomyces cerevisiae.
@ast
A lesion in the DNA replicatio ...... s in Saccharomyces cerevisiae.
@en
A lesion in the DNA replicatio ...... s in Saccharomyces cerevisiae.
@nl
P2093
P2860
P3181
P356
P1476
A lesion in the DNA replicatio ...... s in Saccharomyces cerevisiae.
@en
P2093
P2860
P304
P3181
P356
10.1128/MCB.17.6.3261
P407
P577
1997-06-01T00:00:00Z