Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control.
about
Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cellsIsolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinaseA mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alphaAssociation of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activationCrystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and MammalsYIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation.Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activitySeparate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells.IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowthEnhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cellsIntegration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast.Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase.Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation.Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms.Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.A GCN2-Like eIF2α Kinase (LdeK1) of Leishmania donovani and Its Possible Role in Stress Response.Solution structure of the RWD domain of the mouse GCN2 proteinReceptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeastActivation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation.The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment.Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity.Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2).The abundance of Met30p limits SCF(Met30p) complex activity and is regulated by methionine availability.Amino Acid Sensor Kinase Gcn2 Is Required for Conidiation, Secondary Metabolism, and Cell Wall Integrity in the Taxol-Producer Pestalotiopsis microspora.Transient inhibition of translation initiation by osmotic stress.Serine 577 is phosphorylated and negatively affects the tRNA binding and eIF2alpha kinase activities of GCN2.Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions.Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.
P2860
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P2860
Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Ribosome-binding domain of euk ...... cilitates translation control.
@ast
Ribosome-binding domain of euk ...... cilitates translation control.
@en
Ribosome-binding domain of euk ...... cilitates translation control.
@nl
type
label
Ribosome-binding domain of euk ...... cilitates translation control.
@ast
Ribosome-binding domain of euk ...... cilitates translation control.
@en
Ribosome-binding domain of euk ...... cilitates translation control.
@nl
prefLabel
Ribosome-binding domain of euk ...... cilitates translation control.
@ast
Ribosome-binding domain of euk ...... cilitates translation control.
@en
Ribosome-binding domain of euk ...... cilitates translation control.
@nl
P2860
P3181
P356
P1476
Ribosome-binding domain of euk ...... cilitates translation control.
@en
P2860
P304
P3181
P356
10.1074/JBC.273.3.1808
P407
P577
1998-01-16T00:00:00Z