Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.
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Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals?The structure of the PERK kinase domain suggests the mechanism for its activationEvidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activityPhosphorylation of initiation factor eIF2 in response to stress conditions is mediated by acidic ribosomal P1/P2 proteins in Saccharomyces cerevisiae.A Src-like inactive conformation in the abl tyrosine kinase domainCan the energy gap in the protein-ligand binding energy landscape be used as a descriptor in virtual ligand screening?Allosteric activation by dimerization of the PknD receptor Ser/Thr protein kinase from Mycobacterium tuberculosisPfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvationAdaptability in protein structures: structural dynamics and implications in ligand design.Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cellsAmino acid homeostasis and signalling in mammalian cells and organisms.Structural determinants of PERK inhibitor potency and selectivityCo-conserved features associated with cis regulation of ErbB tyrosine kinases.Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4.Intracellular eukaryotic parasites have a distinct unfolded protein response.Binding site multiplicity with fatty acid ligands: implications for the regulation of PKR kinase autophosphorylation with palmitateConserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK.Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium.Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms.Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module.The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition.Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.Accelerated evolution of maribavir resistance in a cytomegalovirus exonuclease domain II mutant.Activation of PKR: an open and shut case?Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii.Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae.Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeastA network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.Discovery of protein-DNA interactions by penalized multivariate regression.EIF2AK4 mutation as "second hit" in hereditary pulmonary arterial hypertension.Activation of SsoPK4, an Archaeal eIF2α Kinase Homolog, by Oxidized CoA.Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway.Auto-phosphorylation Represses Protein Kinase R Activity.Cellular and animal indispensable amino acid limitation responses and health promotion. Can the two be linked? A critical review.Targeting the unactivated conformations of protein kinases for small molecule drug discovery.Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation.
P2860
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P2860
Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structural basis for autoinhib ...... or 2alpha protein kinase GCN2.
@ast
Structural basis for autoinhib ...... or 2alpha protein kinase GCN2.
@en
Structural basis for autoinhib ...... or 2alpha protein kinase GCN2.
@nl
type
label
Structural basis for autoinhib ...... or 2alpha protein kinase GCN2.
@ast
Structural basis for autoinhib ...... or 2alpha protein kinase GCN2.
@en
Structural basis for autoinhib ...... or 2alpha protein kinase GCN2.
@nl
prefLabel
Structural basis for autoinhib ...... or 2alpha protein kinase GCN2.
@ast
Structural basis for autoinhib ...... or 2alpha protein kinase GCN2.
@en
Structural basis for autoinhib ...... or 2alpha protein kinase GCN2.
@nl
P2093
P2860
P356
P1476
Structural basis for autoinhib ...... or 2alpha protein kinase GCN2.
@en
P2093
Alan G Hinnebusch
Anil K Padyana
Hongfang Qiu
P2860
P304
29289-29299
P356
10.1074/JBC.M504096200
P407
P577
2005-06-17T00:00:00Z