Sestrins inhibit mTORC1 kinase activation through the GATOR complex
about
Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signalingAdvances in Autophagy Regulatory MechanismsSestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose TissueNutrient-sensing mechanisms across evolutionThe apo-structure of the leucine sensor Sestrin2 is still elusiveA lysosome-centered view of nutrient homeostasisBeyond indigestion: emerging roles for lysosome-based signaling in human diseaseJanus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domainsStructural basis for leucine sensing by the Sestrin2-mTORC1 pathwayThe GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome FunctionSestrin2 is a leucine sensor for the mTORC1 pathwayThe CASTOR Proteins Are Arginine Sensors for the mTORC1 PathwayThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingSZT2 dictates GATOR control of mTORC1 signalling.Mechanism of arginine sensing by CASTOR1 upstream of mTORC1Identification of an AMPK phosphorylation site in Drosophila TSC2 (gigas) that regulate cell growthSEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway.The potential of sestrins as therapeutic targets for diabetes.p53 and rapamycin are additive.The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.Multiple amino acid sensing inputs to mTORC1.Sestrin regulation of TORC1: Is Sestrin a leucine sensor?p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing.Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling.Unsolved mysteries of Rag GTPase signaling in yeast.Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathwayA sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during agingThe opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control.Gaining Insights into Diabetic Cardiomyopathy from Drosophila.DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.Rag GTPase in amino acid signaling.mTOR Signaling in Growth, Metabolism, and Disease.Mitochondrial AKAP1 supports mTOR pathway and tumor growth.Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress.Biochemical Basis of Sestrin Physiological Activities.Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation.Leucine and Mammalian Target of Rapamycin-Dependent Activation of Muscle Protein Synthesis in Aging.
P2860
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P2860
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
description
2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2014
@ast
im November 2014 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2014/11/20)
@sk
vědecký článek publikovaný v roce 2014
@cs
wetenschappelijk artikel (gepubliceerd op 2014/11/20)
@nl
наукова стаття, опублікована в листопаді 2014
@uk
مقالة علمية (نشرت في 20-11-2014)
@ar
name
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
@ast
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
@en
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
@nl
type
label
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
@ast
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
@en
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
@nl
prefLabel
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
@ast
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
@en
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
@nl
P2093
P2860
P921
P3181
P1433
P1476
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
@en
P2093
Aida Nourbakhsh
Andrei V. Budanov
Anita Parmigiani
Boxiao Ding
Konstantin Akopiants
Kun-Liang Guan
Young Chul Kim
P2860
P304
P3181
P356
10.1016/J.CELREP.2014.10.019
P577
2014-11-20T00:00:00Z