The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
about
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signalingThe Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and MetabolismAdvances in Autophagy Regulatory MechanismsInhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondRegulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glanceSestrin2, a Regulator of Thermogenesis and Mitohormesis in Brown Adipose TissueNutrient-sensing mechanisms across evolutionThe apo-structure of the leucine sensor Sestrin2 is still elusiveThe impact of protein quality on the promotion of resistance exercise-induced changes in muscle massA lysosome-centered view of nutrient homeostasisBeyond indigestion: emerging roles for lysosome-based signaling in human diseaseJanus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domainsStructural basis for leucine sensing by the Sestrin2-mTORC1 pathwaySestrins inhibit mTORC1 kinase activation through the GATOR complexThe GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome FunctionSestrin2 is a leucine sensor for the mTORC1 pathwayThe CASTOR Proteins Are Arginine Sensors for the mTORC1 PathwayThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingSestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signalingSZT2 dictates GATOR control of mTORC1 signalling.Current Concepts and Unresolved Questions in Dietary Protein Requirements and Supplements in Adults.Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle.Mechanism of arginine sensing by CASTOR1 upstream of mTORC1Nutrient-sensing mechanisms and pathways.Identification of an AMPK phosphorylation site in Drosophila TSC2 (gigas) that regulate cell growthSEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway.The potential of sestrins as therapeutic targets for diabetes.Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade.The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma CellsGCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.Multiple amino acid sensing inputs to mTORC1.Sestrin2 expression is a favorable prognostic factor in patients with non-small cell lung cancer.Sestrin regulation of TORC1: Is Sestrin a leucine sensor?p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing.
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P2860
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
description
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2014
@ast
im Oktober 2014 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2014/10/09)
@sk
vědecký článek publikovaný v roce 2014
@cs
wetenschappelijk artikel (gepubliceerd op 2014/10/09)
@nl
наукова стаття, опублікована в жовтні 2014
@uk
مقالة علمية (نشرت في 9-10-2014)
@ar
name
The Sestrins interact with GAT ...... ing pathway upstream of mTORC1
@ast
The Sestrins interact with GAT ...... ing pathway upstream of mTORC1
@en
The Sestrins interact with GAT ...... ing pathway upstream of mTORC1
@nl
type
label
The Sestrins interact with GAT ...... ing pathway upstream of mTORC1
@ast
The Sestrins interact with GAT ...... ing pathway upstream of mTORC1
@en
The Sestrins interact with GAT ...... ing pathway upstream of mTORC1
@nl
prefLabel
The Sestrins interact with GAT ...... ing pathway upstream of mTORC1
@ast
The Sestrins interact with GAT ...... ing pathway upstream of mTORC1
@en
The Sestrins interact with GAT ...... ing pathway upstream of mTORC1
@nl
P2093
P2860
P921
P3181
P1433
P1476
The Sestrins interact with GAT ...... ing pathway upstream of mTORC1
@en
P2093
David M. Sabatini
Eric Spooner
Jose M. Orozco
Liron Bar-Peled
Lynne Chantranupong
Marta Isasa
Rachel L. Wolfson
Robert A. Saxton
Sonia M. Scaria
P2860
P3181
P356
10.1016/J.CELREP.2014.09.014
P577
2014-10-09T00:00:00Z