Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes
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Dissecting Alzheimer disease in Down syndrome using mouse modelsA genetic cause of Alzheimer disease: mechanistic insights from Down syndromeSynaptic Vesicle Recycling Is Unaffected in the Ts65Dn Mouse Model of Down SyndromeIncreasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer's disease patientsThe Sac domain-containing phosphoinositide phosphatases: structure, function, and diseaseActivity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinaseDysregulation of protein trafficking in neurodegeneration.Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments.Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's diseaseInter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APPEvidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.Down syndrome and Alzheimer's disease: Common pathways, common goals.Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's disease.Allogeneic T cell responses are regulated by a specific miRNA-mRNA network.Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society.Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.The role of phosphoinositides in synapse function.Inositol lipid phosphatases in membrane trafficking and human disease.Synaptojanin 1 mutation in Parkinson's disease brings further insight into the neuropathological mechanisms.Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges.Down syndrome and the complexity of genome dosage imbalance.Screening of potential biomarkers for prenatal diagnosis of trisomy 21.Genome-wide gene expression analysis in the placenta from fetus with trisomy 21.Dysregulation of neurotrophin signaling in the pathogenesis of Alzheimer disease and of Alzheimer disease in Down syndrome.Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.Exosomal biomarkers in Down syndrome and Alzheimer's disease.Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease.Alteration of endosomal trafficking is associated with early-onset parkinsonism caused by SYNJ1 mutations.Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.
P2860
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P2860
Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes
description
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2012
@ast
im Juli 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2012/07/15)
@sk
vědecký článek publikovaný v roce 2012
@cs
wetenschappelijk artikel (gepubliceerd op 2012/07/15)
@nl
наукова стаття, опублікована в липні 2012
@uk
مقالة علمية (نشرت في 15-7-2012)
@ar
name
Trisomy for synaptojanin1 in D ...... enlargement of early endosomes
@ast
Trisomy for synaptojanin1 in D ...... enlargement of early endosomes
@en
Trisomy for synaptojanin1 in D ...... enlargement of early endosomes
@nl
type
label
Trisomy for synaptojanin1 in D ...... enlargement of early endosomes
@ast
Trisomy for synaptojanin1 in D ...... enlargement of early endosomes
@en
Trisomy for synaptojanin1 in D ...... enlargement of early endosomes
@nl
prefLabel
Trisomy for synaptojanin1 in D ...... enlargement of early endosomes
@ast
Trisomy for synaptojanin1 in D ...... enlargement of early endosomes
@en
Trisomy for synaptojanin1 in D ...... enlargement of early endosomes
@nl
P2093
P2860
P50
P921
P356
P1476
Trisomy for synaptojanin1 in D ...... enlargement of early endosomes
@en
P2093
Charles Duyckaerts
Clotilde Mircher
Clémentine Ripoll
Diego E. Berman
Gilbert Di Paolo
Isabelle Rivals
Jack-Christophe Cossec
Jean M. Delabar
Jean-Christophe Olivomarin
Joris A. Veltman
P2860
P304
P356
10.1093/HMG/DDS142
P577
2012-07-15T00:00:00Z