Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model. - Wikidata - wikimedia - TriplyDB

Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.

Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.

http://www.wikidata.org/entity/Q37272217

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A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.Arf6 and the 5'phosphatase of Synaptojanin 1 regulate autophagy in cone photoreceptors The role of phosphoinositides in synapse function.Inositol lipid phosphatases in membrane trafficking and human disease.Synaptojanin 1 mutation in Parkinson's disease brings further insight into the neuropathological mechanisms.Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges.Down syndrome and the complexity of genome dosage imbalance.Genome-wide gene expression analysis in the placenta from fetus with trisomy 21.ApoE4-associated phospholipid dysregulation contributes to development of Tau hyper-phosphorylation after traumatic brain injury.Genome-wide DNA methylation changes associated with olfactory learning and memory in Apis mellifera.Alteration of endosomal trafficking is associated with early-onset parkinsonism caused by SYNJ1 mutations.Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease.Non-Coding RNA Mediated Regulation of Allogeneic T Cell Responses After Hematopoietic Transplantation.Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.

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Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.

http://www.wikidata.org/entity/Q37272217

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 19 September 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Reduction of synaptojanin 1 ac ...... n in an Alzheimer mouse model.

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Reduction of synaptojanin 1 ac ...... n in an Alzheimer mouse model.

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Reduction of synaptojanin 1 ac ...... n in an Alzheimer mouse model.

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Reduction of synaptojanin 1 ac ...... n in an Alzheimer mouse model.

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Reduction of synaptojanin 1 ac ...... n in an Alzheimer mouse model.

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JBC.M113.504365

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Journal of Biological Chemistry

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Reduction of synaptojanin 1 ac ...... on in an Alzheimer mouse model

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Hannah Rhee

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Ina Caesar

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Jiaying Zhao

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Laura Volpicelli-Daley

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Li Zhu

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Lijuan Liu

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Louise Lucast

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Michelle E Ehrlich

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Minghao Zhong

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Nikolaos K Robakis

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P2860

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.

HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes

Cellular mechanisms of γ-secretase substrate selection, processing and toxicity

Dynamin 1 regulates amyloid generation through modulation of BACE-1

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

Proteolytic processing of Alzheimer's β-amyloid precursor protein

Essential role of phosphoinositide metabolism in synaptic vesicle recycling

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32050-32063

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scholarly article

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10.1074/JBC.M113.504365

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44

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288

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Elysse M Knight

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2013-09-19T00:00:00Z

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24052255

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Alzheimer's disease

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3814799

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