The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium

The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium

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http://www.wikidata.org/entity/Q28138149

Q28138149

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Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1 The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5 HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer Teen smoking, field cancerization, and a "critical period" hypothesis for lung cancer susceptibility.Amino acid management in cancer Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity Voltage-gated ion channels in cancer cell proliferation Regulation of mTORC1 by amino acids A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae.A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex Biology and therapy of inherited retinal degenerative disease: insights from mouse models High-resolution chromosome 3p allelotyping of breast carcinomas and precursor lesions demonstrates frequent loss of heterozygosity and a discontinuous pattern of allele loss Chromosome 3p allele loss in early invasive breast cancer: detailed mapping and association with clinicopathological features.A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1 BRCA1-associated protein 1 deficiency in lung adenocarcinoma predicts poor outcome and increased tumor invasion Phase I clinical trial of systemically administered TUSC2(FUS1)-nanoparticles mediating functional gene transfer in humans The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner TUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma.The Ras-association domain family (RASSF) members and their role in human tumourigenesis.Gene expression profiles of epithelial cells microscopically isolated from a breast-invasive ductal carcinoma and a nodal metastasis Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival.High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer.Relationship between tumor and peripheral blood NPRL2 mRNA levels in patients with colorectal adenoma and colorectal cancer.NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway.Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer.RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers.Cripto haploinsufficiency affects in vivo colon tumor development

P2860

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P2860

The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium

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http://www.wikidata.org/entity/Q28138149

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2000 nî lūn-bûn

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2000年の論文

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