Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines
about
Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase deltaGermline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomasDNA polymerase ε and its roles in genome stabilityDNA polymerase delta in DNA replication and genome maintenanceDNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA PolymeraseMutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesisA synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancersDNA replication fidelity and cancerHigh incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreadingReplication protein A is an independent prognostic indicator with potential therapeutic implications in colon cancer.A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.A mutation in POLE predisposing to a multi-tumour phenotype.Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer.Pre-steady state kinetic studies of the fidelity of nucleotide incorporation by yeast DNA polymerase deltaConcurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancerNative homing endonucleases can target conserved genes in humans and in animal models.Cadherin cytoplasmic domains inhibit the cell surface localization of endogenous E-cadherin, blocking desmosome and tight junction formation and inducing cell dissociation.Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelityPools and Pols: Mechanism of a mutator phenotype.A substitution in the fingers domain of DNA polymerase δ reduces fidelity by altering nucleotide discrimination in the catalytic site.DNA polymerases and cancer.DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.Structural insights into yeast DNA polymerase delta by small angle X-ray scattering.Claudin family of proteins and cancer: an overview.Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells.POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologiesEvolutionary dynamics and significance of multiple subclonal mutations in cancer.Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase deltaThe N-terminal region of DNA polymerase delta catalytic subunit is necessary for holoenzyme function.Mutation analysis of replicative genes encoding the large subunits of DNA polymerase alpha and replication factors A and C in human sporadic colorectal cancers.Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences.Family A and B DNA Polymerases in Cancer: Opportunities for Therapeutic Interventions.
P2860
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P2860
Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Detection of mutations in the ...... rs and colon cancer cell lines
@ast
Detection of mutations in the ...... rs and colon cancer cell lines
@en
Detection of mutations in the ...... rs and colon cancer cell lines
@nl
type
label
Detection of mutations in the ...... rs and colon cancer cell lines
@ast
Detection of mutations in the ...... rs and colon cancer cell lines
@en
Detection of mutations in the ...... rs and colon cancer cell lines
@nl
prefLabel
Detection of mutations in the ...... rs and colon cancer cell lines
@ast
Detection of mutations in the ...... rs and colon cancer cell lines
@en
Detection of mutations in the ...... rs and colon cancer cell lines
@nl
P2093
P2860
P1476
Detection of mutations in the ...... rs and colon cancer cell lines
@en
P2093
P2860
P304
P356
10.1002/(SICI)1097-0215(19990315)80:6<919::AID-IJC19>3.0.CO;2-U
P407
P577
1999-03-15T00:00:00Z