High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading
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An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophyStructural basis of high-fidelity DNA synthesis by yeast DNA polymerase deltaGermline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomasThe fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerasesDNA polymerase ε and its roles in genome stabilitySomatic mosaicism in the human genomeDNA polymerase delta in DNA replication and genome maintenanceAntimutator variants of DNA polymerasesGermline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator miceThe crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partneringAlteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamicsThe C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit.Mutation at the polymerase active site of mouse DNA polymerase delta increases genomic instability and accelerates tumorigenesisReplicative DNA polymerase δ but not ε proofreads errors in Cis and in TransA panoply of errors: polymerase proofreading domain mutations in cancermiR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB RepairAge-dependent down-regulation of DNA polymerase δ1 in human lymphocytesDNA polymerase ε and δ exonuclease domain mutations in endometrial cancerDNA replication fidelity and cancerThe human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysisDNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primersDNA replication error-induced extinction of diploid yeastArsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanismsMolecular features in arsenic-induced lung tumorsDNA polymerase delta is required for early mammalian embryogenesis.Mutator mutations enhance tumorigenic efficiency across fitness landscapes.Normally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variantA cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability.The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis.Mutator suppression and escape from replication error-induced extinction in yeastPre-steady state kinetic studies of the fidelity of nucleotide incorporation by yeast DNA polymerase deltaActive site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression.Kinetic approaches to understanding the mechanisms of fidelity of the herpes simplex virus type 1 DNA polymeraseIncreased frequency of single base substitutions in a population of transcripts expressed in cancer cells.Use of somatic mutations to quantify random contributions to mouse developmentConcurrent genetic alterations in DNA polymerase proofreading and mismatch repair in human colorectal cancerPolymerase ɛ (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing.A random mutation capture assay to detect genomic point mutations in mouse tissueThe in vitro fidelity of yeast DNA polymerase δ and polymerase ε holoenzymes during dinucleotide microsatellite DNA synthesis.Volatility of Mutator Phenotypes at Single Cell Resolution
P2860
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P2860
High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading
description
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2002
@ast
im November 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/11/26)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/11/26)
@nl
наукова стаття, опублікована в листопаді 2002
@uk
name
High incidence of epithelial c ...... polymerase delta proofreading
@ast
High incidence of epithelial c ...... polymerase delta proofreading
@en
High incidence of epithelial c ...... polymerase delta proofreading
@nl
type
label
High incidence of epithelial c ...... polymerase delta proofreading
@ast
High incidence of epithelial c ...... polymerase delta proofreading
@en
High incidence of epithelial c ...... polymerase delta proofreading
@nl
prefLabel
High incidence of epithelial c ...... polymerase delta proofreading
@ast
High incidence of epithelial c ...... polymerase delta proofreading
@en
High incidence of epithelial c ...... polymerase delta proofreading
@nl
P2093
P2860
P356
P1476
High incidence of epithelial c ...... polymerase delta proofreading
@en
P2093
Bradley D. Preston
Elise A. Olmsted
Gerry J. Spangrude
Laura E. Hays
Robert E. Goldsby
William B. Slayton
P2860
P304
15560–15565
P356
10.1073/PNAS.232340999
P407
P577
2002-11-26T00:00:00Z