Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression
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The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9Purification and characterization of human DNA damage checkpoint Rad complexesHuman checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cellsMolecular modeling-based analysis of interactions in the RFC-dependent clamp-loading processCharacterization of DNA damage-stimulated self-interaction of Saccharomyces cerevisiae checkpoint protein Rad17p.PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibitionReconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complexHistone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stressStructures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopyA role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complexThe effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of nonhomologous end-joiningFrag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis.ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation.Preferential binding of ATR protein to UV-damaged DNA.DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein.The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe.RAD9 deficiency enhances radiation induced bystander DNA damage and transcriptomal responseHuman RAD9 checkpoint control/proapoptotic protein can activate transcription of p21.The role of RAD9 in tumorigenesis.A role for the arginine methylation of Rad9 in checkpoint control and cellular sensitivity to DNA damage.Association of the Rad9-Rad1-Hus1 checkpoint clamp with MYH DNA glycosylase and DNA.Recruitment of the Rad9-Hus1-Rad1 complex to DNATargeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeastPhysical and functional interactions between MutY glycosylase homologue (MYH) and checkpoint proteins Rad9-Rad1-Hus1.p53 and RAD9, the DNA Damage Response, and Regulation of Transcription Networks.Mutant alleles of Schizosaccharomyces pombe rad9(+) alter hydroxyurea resistance, radioresistance and checkpoint control.Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling.Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethalityThe role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint.
P2860
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P2860
Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression
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2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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Physical interactions among hu ...... tion of cell cycle progression
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Physical interactions among hu ...... tion of cell cycle progression
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Physical interactions among hu ...... tion of cell cycle progression
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Physical interactions among hu ...... tion of cell cycle progression
@ast
Physical interactions among hu ...... tion of cell cycle progression
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Physical interactions among hu ...... tion of cell cycle progression
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Physical interactions among hu ...... tion of cell cycle progression
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Physical interactions among hu ...... tion of cell cycle progression
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Physical interactions among hu ...... tion of cell cycle progression
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P356
P1433
P1476
Physical interactions among hu ...... tion of cell cycle progression
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P2093
P356
10.1006/GENO.2000.6142
P407
P577
2000-04-01T00:00:00Z