Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies
about
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2C5L2 is a functional receptor for acylation-stimulating proteinDistinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylationPushing the envelope in the mTOR pathway: the second generation of inhibitorsTwo motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptorActivation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1Hierarchical phosphorylation of the translation inhibitor 4E-BP1Activation of mammalian target of rapamycin contributes to pain nociception induced in rats by BmK I, a sodium channel-specific modulatorA role for PYK2 in ANG II-dependent regulation of the PHAS-1-eIF4E complex by multiple signaling cascades in vascular smooth muscleCaspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motifNew hierarchical phosphorylation pathway of the translational repressor eIF4E-binding protein 1 (4E-BP1) in ischemia-reperfusion stressThe rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E.TOR signaling.Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryoMammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR.Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.Intracellular parasitism with Toxoplasma gondii stimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1.mTORC1 directly phosphorylates and regulates human MAF1.4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency.Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor.Mechanical stimulation induces mTOR signaling via an ERK-independent mechanism: implications for a direct activation of mTOR by phosphatidic acid.Mutational analysis of the EMCV 2A protein identifies a nuclear localization signal and an eIF4E binding site.Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins.Curcumin disrupts the Mammalian target of rapamycin-raptor complex.Regulation of mRNA translation in renal physiology and disease.Threonine affects intestinal function, protein synthesis and gene expression of TOR in Jian carp (Cyprinus carpio var. Jian).Regulation of mammalian translation factors by nutrients.Frontier of epilepsy research - mTOR signaling pathway.Alcohol intoxication following muscle contraction in mice decreases muscle protein synthesis but not mTOR signal transduction.Lysophosphatidic acid acyltransferase beta regulates mTOR signalingSerotonin increases phosphorylation of synaptic 4EBP through TOR, but eukaryotic initiation factor 4E levels do not limit somatic cap-dependent translation in aplysia neurons.Purifying mRNAs with a high-affinity eIF4E mutant identifies the short 3' poly(A) end phenotype.Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1
P2860
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P2860
Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Mammalian target of rapamycin- ...... by phospho-specific antibodies
@ast
Mammalian target of rapamycin- ...... by phospho-specific antibodies
@en
Mammalian target of rapamycin- ...... by phospho-specific antibodies
@nl
type
label
Mammalian target of rapamycin- ...... by phospho-specific antibodies
@ast
Mammalian target of rapamycin- ...... by phospho-specific antibodies
@en
Mammalian target of rapamycin- ...... by phospho-specific antibodies
@nl
prefLabel
Mammalian target of rapamycin- ...... by phospho-specific antibodies
@ast
Mammalian target of rapamycin- ...... by phospho-specific antibodies
@en
Mammalian target of rapamycin- ...... by phospho-specific antibodies
@nl
P2093
P2860
P356
P1476
Mammalian target of rapamycin- ...... by phospho-specific antibodies
@en
P2093
C T Capaldo
I Mothe-Satney
J C Lawrence
L P McMahon
R T Abraham
P2860
P304
P356
10.1074/JBC.M006005200
P407
P577
2000-10-27T00:00:00Z