Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
about
ATR suppresses endogenous DNA damage and allows completion of homologous recombination repairA mouse model of ATR-Seckel shows embryonic replicative stress and accelerated agingThe Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genesInteraction between human MCM7 and Rad17 proteins is required for replication checkpoint signalingThe cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repairActivation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firingA DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1BRCT domain-containing protein PTIP is essential for progression through mitosisPhosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damageFunctional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stressTargeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugsMore than blood, a novel gene required for mammalian postimplantation developmentThe replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationThe human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilonTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyATR-mediated regulation of nuclear and cellular plasticityDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerModeling the study of DNA damage responses in miceHistone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stressHuman claspin is required for replication checkpoint controlAtaxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodiesPlk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathwayRecruitment of the cell cycle checkpoint kinase ATR to chromatin during S-phaseNovel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathwayDeletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell lossATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient backgroundCheckpoint kinase 1 in DNA damage response and cell cycle regulationCell cycle roles for two 14-3-3 proteins during Drosophila developmentTargeted inactivation of p12, CDK2 associating protein 1, leads to early embryonic lethalityMutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinaseMammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factorsMutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombinationActivation of the ATR kinase by the RPA-binding protein ETAA1ATR: an essential regulator of genome integrityDNA damage-induced cell death is enhanced by progression through mitosisDistinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.Viral transport of DNA damage that mimics a stalled replication fork.
P2860
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P2860
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
description
2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2000 թվականի ապրիլին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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name
Targeted disruption of the cel ...... ly embryonic lethality in mice
@ast
Targeted disruption of the cel ...... ly embryonic lethality in mice
@en
Targeted disruption of the cel ...... ly embryonic lethality in mice
@nl
type
label
Targeted disruption of the cel ...... ly embryonic lethality in mice
@ast
Targeted disruption of the cel ...... ly embryonic lethality in mice
@en
Targeted disruption of the cel ...... ly embryonic lethality in mice
@nl
prefLabel
Targeted disruption of the cel ...... ly embryonic lethality in mice
@ast
Targeted disruption of the cel ...... ly embryonic lethality in mice
@en
Targeted disruption of the cel ...... ly embryonic lethality in mice
@nl
P2093
P3181
P1433
P1476
Targeted disruption of the cel ...... ly embryonic lethality in mice
@en
P2093
A R Lehmann
A de Klein
J H Hoeijmakers
M Muijtjens
Y Verhoeven
P304
P3181
P356
10.1016/S0960-9822(00)00447-4
P407
P577
2000-04-20T00:00:00Z