Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator
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Modulation of PAX6 homeodomain function by the paired domainAcetyltransferase p300 regulates NBS1-mediated DNA damage responseTCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3betaPax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and functionConditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell developmentInsulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactionsThe HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoterThe transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanismFatty acids in component of milk enhance the expression of the cAMP-response-element-binding-protein-binding protein (CBP)/p300 gene in developing ratsPhosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2The activation of the rat insulin gene II by BETA2 and PDX-1 in rat insulinoma cells is repressed by Pax6Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression.Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase BPax6; a pleiotropic player in development.Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens.Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens.Transcriptional networks driving enhancer function in the CFTR gene.MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.Genetic and epigenetic mechanisms of gene regulation during lens development.Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development.Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers.MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cellsHistone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.Interaction of Maf transcription factors with Pax-6 results in synergistic activation of the glucagon promoter.Insulin responsiveness of the glucagon gene conferred by interactions between proximal promoter and more distal enhancer-like elements involving the paired-domain transcription factor Pax6.Targeting pancreatic expressed PAX genes for the treatment of diabetes mellitus and pancreatic neuroendocrine tumors.Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells.Structure-Function Analysis of the Drosophila melanogaster Caudal Transcription Factor Provides Insights into Core Promoter-preferential ActivationTranscriptional reprogramming and chromatin remodeling accompanies Oct4 and Nanog silencing in mouse trophoblast lineage.Analysis of the transcription factor cascade that induces endocrine and exocrine cell lineages from pancreatic progenitor cells using a polyoma-based episomal vector system.Nkx6.2 synergizes with Cdx-2 in stimulating proglucagon gene expression.Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2.POU homeodomain protein Oct-1 functions as a sensor for cyclic AMP.Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.Protein kinase B activity is sufficient to mimic the effect of insulin on glucagon gene transcription.Functional interactions between alternatively spliced forms of Pax6 in crystallin gene regulation and in haploinsufficiency.Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression.Specific Pax-6/microphthalmia transcription factor interactions involve their DNA-binding domains and inhibit transcriptional properties of both proteins.Gene regulation by PAX6: structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204.
P2860
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P2860
Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Glucagon gene transcription ac ...... x-2 with the p300 co-activator
@ast
Glucagon gene transcription ac ...... x-2 with the p300 co-activator
@en
Glucagon gene transcription ac ...... x-2 with the p300 co-activator
@nl
type
label
Glucagon gene transcription ac ...... x-2 with the p300 co-activator
@ast
Glucagon gene transcription ac ...... x-2 with the p300 co-activator
@en
Glucagon gene transcription ac ...... x-2 with the p300 co-activator
@nl
prefLabel
Glucagon gene transcription ac ...... x-2 with the p300 co-activator
@ast
Glucagon gene transcription ac ...... x-2 with the p300 co-activator
@en
Glucagon gene transcription ac ...... x-2 with the p300 co-activator
@nl
P2860
P3181
P356
P1476
Glucagon gene transcription ac ...... x-2 with the p300 co-activator
@en
P2093
J F Habener
M A Hussain
P2860
P304
P3181
P356
10.1074/JBC.274.41.28950
P407
P577
1999-10-08T00:00:00Z