POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element
about
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cellsGlucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activatorInactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivoPdx1 level defines pancreatic gene expression pattern and cell lineage differentiationFoxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expressionNovel domain-specific POU3F4 mutations are associated with X-linked deafness: examples from different populations.Cytoplasmic mislocalization of POU3F4 due to novel mutations leads to deafness in humans and mice.Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cellsTranscriptional regulation of α-cell differentiation.In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion.Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.Opposing actions of Arx and Pax4 in endocrine pancreas developmentThe endocrine pancreas: insights into development, differentiation, and diabetes.Interaction of Maf transcription factors with Pax-6 results in synergistic activation of the glucagon promoter.Pou homeodomain protein OCT1 is implicated in the expression of the caudal-related homeobox gene Cdx-2.Insulin responsiveness of the glucagon gene conferred by interactions between proximal promoter and more distal enhancer-like elements involving the paired-domain transcription factor Pax6.Role of transcription factors in the transdifferentiation of pancreatic islet cells.Nkx6.2 synergizes with Cdx-2 in stimulating proglucagon gene expression.Clinical and molecular characterizations of novel POU3F4 mutations reveal that DFN3 is due to null function of POU3F4 protein.Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells.Repression of glucagon gene transcription by peroxisome proliferator-activated receptor gamma through inhibition of Pax6 transcriptional activity.Divergent regulation of human and rat proglucagon gene promoters in vivo.Pax6 and Cdx2/3 form a functional complex on the rat glucagon gene promoter G1-element.MafB is critical for glucagon production and secretion in mouse pancreatic α-cells in vivo.Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells.
P2860
Q24642447-DAB4475A-7BDD-4B33-8BC1-298E3DEE3AF6Q28145350-7B4AEAB5-E127-4A05-B20D-CC0852A3A23FQ28507284-1BCA794A-AEDE-4E9B-AF19-5926DB15E3B3Q28573262-8BD70BF2-894A-4F28-92B5-DCF9EAB1DC35Q28771373-C0494D0C-4936-4557-9332-6BC72CAA7CB2Q30412441-6703DEE0-DBD6-4103-A50A-40B4567B6DA1Q30433617-65EE2F86-C7A8-4263-A929-0AFE8E2ECEC4Q33642038-080714C5-EC98-467A-8097-96735EAAAB59Q34206599-644D02F3-8AB9-4E5D-9A03-3072E61968EBQ34967985-3D4866C7-AB4A-4BCC-B78F-FCD97B7A00E2Q35193221-E070BA3F-540D-47F0-B752-29348EF6633AQ36336824-285F5386-A3B5-486E-B465-D445C764C4EDQ38116916-AA3638CD-BFA5-4772-9364-288648ADB3A7Q38298910-3170F63B-9638-4A7D-8F34-13E3189B37DFQ38302708-AC34987B-40D8-43C4-94CD-BEC86D22CB03Q38311220-5585AFD6-F247-4EAA-A912-B60EDD778D72Q38384412-7116C7FC-EF71-4201-9823-B9AD07A8F19EQ39520946-289A5DB2-F5A0-4547-B272-8E4B2FA8E3E8Q39813941-A8D9D7F9-889E-4356-B617-10911DF2BA2BQ40075050-E2798494-AB0B-4942-B3B6-B182B9B34B26Q40691546-DBDD88B3-1BD6-41E5-B5AA-1C526F71313DQ40768808-6D96A03D-4C6C-42C0-AB95-D6F4DC5A507AQ40923840-A0D61472-9F69-4E56-9F85-0D689D6DF27CQ42817811-5156C706-CA47-4E81-8CA7-CDC161BE0DBEQ47639721-AE8BCDAF-5048-4010-A4F0-30CBA7DF356AQ52124155-E907F85E-BD06-4609-B15A-FC6B32AC6F56
P2860
POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element
description
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1997
@ast
im Dezember 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/12/01)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/12/01)
@nl
наукова стаття, опублікована в грудні 1997
@uk
مقالة علمية نشرت في ديسمبر 1997 حول موضوع: دماغ
@ar
name
POU domain transcription facto ...... l proximal promoter G1 element
@ast
POU domain transcription facto ...... l proximal promoter G1 element
@en
POU domain transcription facto ...... l proximal promoter G1 element
@nl
type
label
POU domain transcription facto ...... l proximal promoter G1 element
@ast
POU domain transcription facto ...... l proximal promoter G1 element
@en
POU domain transcription facto ...... l proximal promoter G1 element
@nl
prefLabel
POU domain transcription facto ...... l proximal promoter G1 element
@ast
POU domain transcription facto ...... l proximal promoter G1 element
@en
POU domain transcription facto ...... l proximal promoter G1 element
@nl
P2093
P2860
P356
P1476
POU domain transcription facto ...... l proximal promoter G1 element
@en
P2093
C. P. Miller
J. F. Habener
M. A. Hussain
P2860
P304
P356
10.1128/MCB.17.12.7186
P407
P577
1997-12-01T00:00:00Z