ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15. - Wikidata - wikimedia - TriplyDB

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

http://www.wikidata.org/entity/Q30441580

about

Regulation of brain-derived neurotrophic factor exon IV transcription through calcium responsive elements in cortical neurons Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities RSK isoforms in cancer cell invasion and metastasis How does a protein with dual mitotic spindle and extracellular matrix receptor functions affect tumor susceptibility and progression?PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities.Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.A phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells.Characterization of a MAPK scaffolding protein logic gate in gonadotropes.Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model PLD1 participates in BDNF-induced signalling in cortical neurons Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2.PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival.Targetting PED/PEA-15 for diabetes treatment.Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.Mechanism of sustained activation of ribosomal S6 kinase (RSK) and ERK by kaposi sarcoma-associated herpesvirus ORF45: multiprotein complexes retain active phosphorylated ERK AND RSK and protect them from dephosphorylation.PED/PEA-15 interacts with the 67 kD laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis.Phospholipase Cϵ Activates Nuclear Factor-κB Signaling by Causing Cytoplasmic Localization of Ribosomal S6 Kinase and Facilitating Its Phosphorylation of Inhibitor κB in Colon Epithelial Cells.R-Ras interacts with filamin a to maintain endothelial barrier function.NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites.Circadian expression and functional characterization of PEA-15 within the mouse suprachiasmatic nucleus.

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P2860

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

http://www.wikidata.org/entity/Q30441580

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

@ast

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

@en

type

label

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

@ast

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

@en

prefLabel

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

@ast

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

@en

P1433

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P356

PNAS.0704514104

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

@en

P2093

Hema Renganathan

http://www.w3.org/2001/XMLSchema#string

Hema Vaidyanathan

http://www.w3.org/2001/XMLSchema#string

John Opoku-Ansah

http://www.w3.org/2001/XMLSchema#string

Michelle L Matter

http://www.w3.org/2001/XMLSchema#string

Sandra Pastorino

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

Signaling through scaffold, anchoring, and adaptor proteins

Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis

RSK2 activity is regulated by its interaction with PEA-15

Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

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19837-19842

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scholarly article

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10.1073/PNAS.0704514104

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50

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104

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2007-12-06T00:00:00Z

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5771990

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18077417

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P932

2148384

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