PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase - Wikidata - wikimedia - TriplyDB

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

http://www.wikidata.org/entity/Q28204643

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Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum Mxi2 promotes stimulus-independent ERK nuclear translocation Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5 Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis Raf family kinases: old dogs have learned new tricks PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation The PEA-15 protein regulates autophagy via activation of JNK Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy?On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain RETRACTED: Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Translocation Is Mediated by Casein Kinase 2 and Accelerated by Autophosphorylation Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK RSK2 activity is regulated by its interaction with PEA-15 Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15 PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence Death effector domain DEDa, a self-cleaved product of caspase-8/Mch5, translocates to the nucleus by binding to ERK1/2 and upregulates procaspase-8 expression via a p53-dependent mechanism Differential regulation and properties of MAPKs Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance Vanishin is a novel ubiquitinylated death-effector domain protein that blocks ERK activation Coordinating ERK/MAPK signalling through scaffolds and inhibitors PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin.Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities.Identification of cell signaling molecules by expression cloning.Localization of ERK/MAP kinase is regulated by the alphaherpesvirus tegument protein Us2 Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.ERK nuclear translocation is dimerization-independent but controlled by the rate of phosphorylation.Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.PEA15 regulates the DNA damage-induced cell cycle checkpoint and oncogene-directed transformation Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.Transcriptional networks and cellular senescence in human mammary fibroblasts.The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.

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P2860

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

http://www.wikidata.org/entity/Q28204643

description

2001 nî lūn-bûn

@nan

2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2001年の論文

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2001年論文

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2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

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2001年論文

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2001年论文

@wuu

name

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

@ast

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

@en

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

@nl

type

label

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

@ast

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

@en

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

@nl

prefLabel

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

@ast

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

@en

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

@nl

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S1534-5807(01)00035-1

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Developmental Cell

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PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

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P2093

B Canton

http://www.w3.org/2001/XMLSchema#string

E Formstecher

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J C Hsieh

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J Camonis

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J V Barnier

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M Fauquet

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M H Ginsberg

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X T Nguyen

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239-250

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scholarly article

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952912

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10.1016/S1534-5807(01)00035-1

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2

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Hervé Chneiweiss

David A Calderwood

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11702783

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