Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling
about
Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activationThe LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alphaGenomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisationPhosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell ActivationPtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanismLipid kinases as therapeutic targets for chronic painRegulation of platelet plug formation by phosphoinositide metabolismPIP kinases define PI4,5P₂signaling specificity by association with effectorsEmerging roles of PtdIns(4,5)P2--beyond the plasma membranePhosphoinositides are essential coactivators for p21-activated kinase 1Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesionA novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gammaElectrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins.Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes.Immunostaining evidence for PI(4,5)P2 localization at the leading edge of chemoattractant-stimulated HL-60 cells.Phosphatidylinositol 4-phosphate 5-kinase alpha (PIPKα) regulates neuronal microtubule depolymerase kinesin, KIF2A and suppresses elongation of axon branches.Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.Type I phosphatidylinositol phosphate kinase beta regulates focal adhesion disassembly by promoting beta1 integrin endocytosisImpact of engagement of FcepsilonRI and CC chemokine receptor 1 on mast cell activation and motility.PIP5KI gamma is required for cardiovascular and neuronal developmentCytoskeletal regulation: rich in lipids.Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migrationLipid rafts and regulation of the cytoskeleton during T cell activation.Phosphatidylinositol-4-phosphate 5-kinase isoforms exhibit acyl chain selectivity for both substrate and lipid activatorSupervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools.Phospholipase D signaling: orchestration by PIP2 and small GTPases.A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family.Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition.Out, in and back again: PtdIns(4,5)P(2) regulates cadherin trafficking in epithelial morphogenesis.Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation.Two novel phosphatidylinositol-4-phosphate 5-kinase type Igamma splice variants expressed in human cells display distinctive cellular targeting.HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures.Regulation of PIP5K activity by Arf6 and its physiological significance.The multifaceted role of PIP2 in leukocyte biology.Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases.Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy CellsPhosphatidylinositol-4-phosphate 5-Kinase 1α Modulates Ribosomal RNA Gene Silencing through Its Interaction with Histone H3 Lysine 9 Trimethylation and Heterochromatin Protein HP1-α.The intracellular localisation and mobility of Type Igamma phosphatidylinositol 4P 5-kinase splice variants.Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42.
P2860
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P2860
Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Membrane ruffling requires coo ...... phate kinase and Rac signaling
@ast
Membrane ruffling requires coo ...... phate kinase and Rac signaling
@en
Membrane ruffling requires coo ...... phate kinase and Rac signaling
@nl
type
label
Membrane ruffling requires coo ...... phate kinase and Rac signaling
@ast
Membrane ruffling requires coo ...... phate kinase and Rac signaling
@en
Membrane ruffling requires coo ...... phate kinase and Rac signaling
@nl
prefLabel
Membrane ruffling requires coo ...... phate kinase and Rac signaling
@ast
Membrane ruffling requires coo ...... phate kinase and Rac signaling
@en
Membrane ruffling requires coo ...... phate kinase and Rac signaling
@nl
P2093
P2860
P3181
P356
P1476
Membrane ruffling requires coo ...... phate kinase and Rac signaling
@en
P2093
Matthew W Bunce
Michelle L Wojtasiak
Renee L Doughman
P2860
P304
23036-23045
P3181
P356
10.1074/JBC.M211397200
P407
P577
2003-04-06T00:00:00Z